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α-Amanitin, 1-L-Asparaginsure-

BETA-AMANITIN Struktur
21150-22-1
CAS-Nr.
21150-22-1
Bezeichnung:
α-Amanitin, 1-L-Asparaginsure-
Englisch Name:
BETA-AMANITIN
Synonyma:
b-Amanitin;β-Amanitin;B-Amanitine;β-Amanitine;BETA-AMANITIN;beta-amatoxin;beta-Amanitine;β-Amanitin DISCONTINUED;1-l-asparticacid-alpha-amaniti;α-Amanitin, 1-L-aspartic acid-
CBNumber:
CB0383204
Summenformel:
C39H53N9O15S
Molgewicht:
919.95
MOL-Datei:
21150-22-1.mol

α-Amanitin, 1-L-Asparaginsure- Eigenschaften

Schmelzpunkt:
300°
Siedepunkt:
1599.6±65.0 °C(Predicted)
Dichte
1.1725 (rough estimate)
Brechungsindex
1.7400 (estimate)
storage temp. 
−20°C
L?slichkeit
Water: 1 mg/ml
pka
4.02±0.10(Predicted)
Aggregatzustand
White to off-white powder.
Farbe
White to off-white

Sicherheit

Kennzeichnung gef?hrlicher T+
R-S?tze: 26/27/28
S-S?tze: 7-28-36/37/39-45
RIDADR  UN 3462 6.1/PG 1
WGK Germany  3
RTECS-Nr. NJ8324000
HazardClass  6.1(a)
PackingGroup  I
HS Code  2934999090
Toxizit?t LD50 i.p. in albino mice: 0.4 mg/kg (Wieland, Wieland)

α-Amanitin, 1-L-Asparaginsure- Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S7:Beh?lter dicht geschlossen halten.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Mechanism of action

β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi. It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis. The biological activity of this toxin is similar to that of α-amanitin but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions.

Allgemeine Beschreibung

β-Amanitin belongs to the family of amatoxins. Amanitins are made of bicyclic octapeptides. β-Amanitin is composed of a carboxyl group and is acidic in nature.

Biochem/physiol Actions

Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.

α-Amanitin, 1-L-Asparaginsure- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


α-Amanitin, 1-L-Asparaginsure- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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Lyla@fengmuchem.com China 2946 58

21150-22-1(α-Amanitin, 1-L-Asparaginsure-)Verwandte Suche:


  • BETA-AMANITIN
  • ,12,17,18,19,20,21,22,23,23a-octadecahydro-29-sec-butyl-2,14-dihydroxy-21-(2,3
  • 1-l-asparticacid-alpha-amaniti
  • 8,20,23,24,27,30,33-octaoxo--dihydroxy-1-methylpropyl)-11-oxide
  • beta-amatoxin
  • B-amanitin from amanita phalloides
  • alpha-Amanitin, 1-l-aspartic acid-
  • beta-Amanitine
  • B-Amanitine
  • β-Amanitin from Amanita phalloides
  • Cyclo[L-Asp-L-t4Hyp-[(3R,4R)-4,5-dihydroxy-3-methyl-L-Nva-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-]
  • b-Amanitin
  • beta-Amanitin from Amanita Phalloides
  • α-Amanitin, 1-L-aspartic acid-
  • β-Amanitin
  • β-Amanitin DISCONTINUED
  • β-Amanitine
  • β-Amanitin from Amanita phalloides
  • 21150-22-1
  • C39H53N9O15S
  • DNA-RNA Transcription Regulators
  • Gene Regulation and Expression
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Cell Signaling and Neuroscience
  • DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience
  • Gene Regulation and Expression
  • Mushroom
  • Toxins and Venoms
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