ANGIOTENSIN II, HUMAN Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
It is known that tumor tissues including metastatic lymph nodes are composed of
newly growing vessels which lack blood flow autoregulation and are influenced only
secondarily by the responding somatic vessels. Human angiotensin II (AT II). a
vasopressor, was introduced in Japan to improve the efficacy of systemic
chemotherapy. In patients with various advanced cancers, i.v. infusion of AT II to
achieve a mean blood pressure of 1.5 times of baseline (but not over 150 mm Hg)
followed by a bolus injection of conventional cytotoxic agents increases blood flow
5-7 fold in tumor tissues and therefore, increases drug delivery to the target tissue
resulting in enhanced chemotherapeutic effects. This induced-hypertension
chemotherapy regimen can be performed safely with minimal side effects.
Verwenden
Cardiopulmonary resuscitation - not yet an approved application
Allgemeine Beschreibung
Functions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. Increases the entry of Ca
2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Activates JAK2 in smooth muscle cells. Activates p125
FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates pp60c-src in vascular smooth muscle cells. Inhibits adenylate cyclase activity in spontaneously hypertensive rats.
ANGIOTENSIN II, HUMAN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte