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MOZ-IN-3

MOZ-IN-3 Struktur
2055397-18-5
CAS-Nr.
2055397-18-5
Englisch Name:
MOZ-IN-3
Synonyma:
MOZ-IN-3;KAT6B inhibitor;KAT6A inhibitor;MOZ-IN-3/WM-8014;WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR;N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide;N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide;WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014;1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide;1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide
CBNumber:
CB03376843
Summenformel:
C20H17FN2O3S
Molgewicht:
384.42
MOL-Datei:
2055397-18-5.mol

MOZ-IN-3 Eigenschaften

Dichte
1.307±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml; DMSO: 33 mg/ml; Ethanol: 2 mg/ml
Aggregatzustand
A crystalline solid
pka
7.15±0.25(Predicted)
Farbe
White to off-white

Sicherheit

MOZ-IN-3 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 μM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 μM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 μM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.

Verwenden

MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.

MOZ-IN-3 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


MOZ-IN-3 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 54)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5738 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266
China 4566 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
klq@cw-bio.com China 4966 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994
2853530910@QQ.com China 8012 62

  • MOZ-IN-3
  • [1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide
  • MOZ-IN-3/WM-8014
  • WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR
  • KAT6B inhibitor
  • KAT6A inhibitor
  • 1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide
  • WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014
  • N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide
  • N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
  • 1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide
  • 2055397-18-5
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