6-HYDROXYDOPAMINE HYDROCHLORIDE
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- CAS-Nr.
- 28094-15-7
- Englisch Name:
- 6-HYDROXYDOPAMINE HYDROCHLORIDE
- Synonyma:
- 6-OHDA;6-Hd HCl;Nsc233898;OxydopaMine HCL;TIMTEC-BB SBB003496;6-Hydroxydopamine hy;6-OHDA hydrochloride;TopaMine Hydrochloride;OxidopaMine Hydrochloride;6-hydroxydopaminechloride
- CBNumber:
- CB0320270
- Summenformel:
- C8H12ClNO3
- Molgewicht:
- 205.64
- MOL-Datei:
- 28094-15-7.mol
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6-HYDROXYDOPAMINE HYDROCHLORIDE Eigenschaften
- Schmelzpunkt:
- 232-233 °C (dec.)(lit.)
- storage temp.
- room temp
- L?slichkeit
- H2O: >50 mg/mL, clear, yellow to brown
- Aggregatzustand
- powder
- Farbe
- off-white to brown
- Wasserl?slichkeit
- H2O: >50mg/mL, clear, yellow to brown
- BRN
- 4274007
- InChI
- InChI=1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
- InChIKey
- QLMRJHFAGVFUAC-UHFFFAOYSA-N
- SMILES
- C1(CCN)=CC(=C(O)C=C1O)O.Cl
- EPA chemische Informationen
- 6-Hydroxydopamine hydrochloride (28094-15-7)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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6-HYDROXYDOPAMINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.
Verwenden
6-hydroxydopamine hydrochloride has been used:
- to induce Parkinson′s disease (PD) in rats
- to analyse cytotoxic effect of 6-OHDA on PC12 cell line
- to induce noradrenergic (NA) neuron deletion from the locus-coeruleus
Allgemeine Beschreibung
Beige solid.
Air & Water Reaktionen
Hygroscopic. Water soluble.
Reaktivit?t anzeigen
A weak acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-HYDROXYDOPAMINE HYDROCHLORIDE emits very toxic fumes.
Brandgefahr
Flash point data for 6-HYDROXYDOPAMINE HYDROCHLORIDE are not available. 6-HYDROXYDOPAMINE HYDROCHLORIDE is probably combustible.
Biologische Aktivit?t
Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.
6-HYDROXYDOPAMINE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-HYDROXYDOPAMINE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 105)Lieferanten
28094-15-7()Verwandte Suche:
- 4-(2-Aminoethyl)-1,2,3-benzenetriol hydrochloride
- 6-Hd HCl
- Nsc233898
- OxidopaMine Hydrochloride
- 2,4,5-TrihydroxyphenethylamineHCl
- 2,4,5-Trihydroxyphenethylaminehydochloride
- 2,4,5-TRIHYDROXYPHENETHYLAMINEYDOCHLORIDE
- 2,4,5-Trihydroxyphenethylamine hydrochloride, 2,5-Dihydroxytyramine hydrochloride, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride, 6-OHDA
- 1,2,3-Benzenetriol, 4-(2-aminoethyl)-, hydrochloride
- 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrochloride
- 2,4,5-TRIHYDROXYPHENETHYLAMINE HYDROCHLORIDE
- 2,5-DIHYDROXYTYRAMINE HYDROCHLORIDE
- 2-(2,4,5-TRIHYDROXYPHENYL)ETHYLAMINE HYDROCHLORIDE
- TIMTEC-BB SBB003496
- 2,4-benzenetriol,5-(2-aminoethyl)-hydrochloride
- 5-(2-aminoethyl)-1,2,4-benzenetriolhydrochloride
- 6-hydroxydopaminechloride
- 5-(2-aminoethyl)-4-hydroxypyrocatechol hydrochloride
- TopaMine Hydrochloride
- 5-(2-aMinoethyl)benzene-1,2,4-triol hydrochloride
- OxydopaMine HCL
- 6-HYDROXYDOPAMINE HYDROCHLORIDE
- 6-Hydroxydopamine hy
- 6-OHDA hydrochloride
- 6-OHDA
- Neuro-2a cells,p-p38,Interleukin Related,p38 MAPK,PC12 cells,Apoptosis,Dopamine Receptor,Mitophagy,neurotoxicity,Autophagy,Oxidopamine hydrochloride,6-OHDA,Prostaglandin E synthase,Cyclooxygenase,Lesch-Nyhan syndrome,inhibit,Mitochondrial Autophagy,PGE2,attention-deficit hyperactivity disorder,Parkinson’s disease,SH-SY5Y cells,Oxidopamine,Caspase,PGE synthase,Inhibitor,COX,6-Hydroxydopamine
- 28094-15-7
- HO3C6H2CH2CH2NH2HCl
- C8H11NO3ClH
- Amino Alcohols
- Building Blocks
- Oxygen Compounds
- Organic Building Blocks
