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MK-2 Inhibitor III

MK-2 Inhibitor III Struktur
1186648-22-5
CAS-Nr.
1186648-22-5
Englisch Name:
MK-2 Inhibitor III
Synonyma:
MK2-IN-3 hydrate;MK-2 Inhibitor III;MK2-IN-3 hydrate, 10 mM in DMSO;MK-2 INHIBITOR III (COMPOUND 16);MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem;2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate;2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate;Inhibitor,MAP kinase activated protein kinase 2,inhibit,MK2 IN 3 hydrate,MAPKAP kinase 2,MK-2-IN-3 hydrate,MAPK activated protein kinase 2,MK2IN3 hydrate,MAPKAPK2 (MK2),Mitogen-activated protein kinase activated protein kinase 2
CBNumber:
CB03136757
Summenformel:
C21H18N4O2
Molgewicht:
358.4
MOL-Datei:
1186648-22-5.mol

MK-2 Inhibitor III Eigenschaften

Schmelzpunkt:
>255°C (dec.)
storage temp. 
+2C to +8C
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Pale yellow solid
Farbe
Off-White to Pale Yellow
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

MK-2 Inhibitor III Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation. MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM). It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets. MK2 inhibitor III prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells (IC50 = 4.4 μM).

Verwenden

MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation. MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM). It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets. MK2 inhibitor III prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells (IC50 = 4.4 μM).[Cayman Chemical]

MK-2 Inhibitor III Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MK-2 Inhibitor III Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 57)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 5944 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994
 2853530910@QQ.com China 8011 62
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312
 liming@bio-fount.com China 9729 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
  • MK-2 Inhibitor III
  • 2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate
  • MK-2 INHIBITOR III (COMPOUND 16)
  • MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem
  • MK2-IN-3 hydrate
  • 2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate
  • Inhibitor,MAP kinase activated protein kinase 2,inhibit,MK2 IN 3 hydrate,MAPKAP kinase 2,MK-2-IN-3 hydrate,MAPK activated protein kinase 2,MK2IN3 hydrate,MAPKAPK2 (MK2),Mitogen-activated protein kinase activated protein kinase 2
  • MK2-IN-3 hydrate, 10 mM in DMSO
  • 1186648-22-5
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