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GlyT2-IN-1

GlyT2-IN-1 Struktur
448947-81-7
CAS-Nr.
448947-81-7
Englisch Name:
GlyT2-IN-1
Synonyma:
Yoda 1;CS-2063;GlyT2-IN-1;GlyT2-IN-1(YODA 1);Yoda1 >=98% (HPLC);Yoda 1 (GlyT2-IN-1);2-((2,6-Dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole;2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine;Pyrazine, 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-;KcsA,Potassium Channel,Akt,Yoda-1,PKB,Inhibitor,A431 cells,Yoda 1,HCAECs,inhibit,Protein kinase B,ERK,Piezo1,Extracellular signal regulated kinases,Endothelial cells,ERK1/2,Piezo Channel,Yoda1
CBNumber:
CB03048654
Summenformel:
C13H8Cl2N4S2
Molgewicht:
355.27
MOL-Datei:
448947-81-7.mol

GlyT2-IN-1 Eigenschaften

Schmelzpunkt:
136 - 138°C
Siedepunkt:
538.4±60.0 °C(Predicted)
Dichte
1.58±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO (Slightly), Methanol (Very Slightly)
pka
-1.32±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2934999090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

GlyT2-IN-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.

Allgemeine Beschreibung

Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).

Biochem/physiol Actions

Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.

GlyT2-IN-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


GlyT2-IN-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 76)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32820 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 31991 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30241 58
Shanxi Xuanran Import and Export Trade Co., Ltd.
+8617735180244
mike_yan@xuanranglobal.com CHINA 4017 58
InvivoChem
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sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38460 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58

  • GlyT2-IN-1
  • Yoda 1
  • GlyT2-IN-1(YODA 1)
  • Yoda 1 (GlyT2-IN-1)
  • Yoda1 >=98% (HPLC)
  • Pyrazine, 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-
  • 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
  • CS-2063
  • 2-((2,6-Dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole
  • KcsA,Potassium Channel,Akt,Yoda-1,PKB,Inhibitor,A431 cells,Yoda 1,HCAECs,inhibit,Protein kinase B,ERK,Piezo1,Extracellular signal regulated kinases,Endothelial cells,ERK1/2,Piezo Channel,Yoda1
  • 448947-81-7
  • C13H8Cl2N4S2
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