Anti-ACEH antibody produced in rabbit Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

All Prestige Antibodies^?Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

Allgemeine Beschreibung

Angiotensin-converting enzyme-2 (ACE2) is a homolog of angiotensin-I converting enzyme (ACE). ACE2 is a member of the renin-angiotensin system (RAS) which performs functions similar to carboxypeptidase. This 805 amino acid protein is localized in human kidney. The ACE2 gene is located at human chromosome Xp22.2. It contains a N-terminal peptidase domain (PD) and the C-terminal collectrin-like domain (CLD).

Biochem/physiol Actions

Angiotensin-converting enzyme (ACE2) catalyzes the degradation of angiotensin (Ang) II to Ang (1-7). The deficiency ACE2 or its inhibition by ang II is implicated in the pathogenesis of cardiac hypertrophy and myocardial dysfunction. ACE2 is multifunctional and is incapable of hydrolyzing bradykinin. In patients with CTD (connective tissue disease), serum autoantibodies suppress ACE2, which leads to a decrease in the physiological levels of vasoprotective agent Ang (1-7) in the vascular milieu. Activation or administration of ACE2 in patients with CTD may serve as a therapeutic method for treating pulmonary arterial hypertension (PAH), or persistent digital ischemia. It also plays a regulatory role in lung diseases and pulmonary fibrosis. The human ACE2 receptor is recognized by severe acute respiratory syndrome (SARS-CoV) coronaviruses (CoVs) 2. This interaction paves a way for the transmission of infection.

Anti-ACEH antibody produced in rabbit Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Anti-ACEH antibody produced in rabbit Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Shanghai guandao biology engineering co., ltd	18818239863 18818239863	3171921642@qq.com	China	9044	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7979	58

---

• Anti-ACE2 antibody produced in rabbit
• Anti-ACEH antibody produced in rabbit
• Anti-ACE-related carboxypeptidase antibody produced in rabbit
• Anti-Angiotensin-converting enzyme 2 precursor antibody produced in rabbit
• Anti-Angiotensin-converting enzyme homolog antibody produced in rabbit
• Anti-ACEH
• Anti-Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
• Anti-DKFZP434A014
• Anti-ACE2