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Cabergoline

Cabergoline Struktur
81409-90-7
CAS-Nr.
81409-90-7
Englisch Name:
Cabergoline
Synonyma:
Dostinex;CG-101;cabergoline powder;Caber;C08187;Dostine;Cabaser;Sogilen;Galastop;FCE-21336
CBNumber:
CB0282495
Summenformel:
C26H37N5O2
Molgewicht:
451.6
MOL-Datei:
81409-90-7.mol

Cabergoline Eigenschaften

Schmelzpunkt:
102-104°C
Dichte
1.156±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: ≥10mg/mL
pka
13.05±0.46(Predicted)
Aggregatzustand
powder
Farbe
White to Off-White
Optische Aktivit?t
[α]/D 61 to 68°, c = 0.5 in dichloromethane
Stabilit?t:
Hygroscopic
InChIKey
KORNTPPJEAJQIU-KJXAQDMKSA-N
SMILES
[C@]12([H])C[C@H](CN(CC=C)[C@]1([H])CC1=CNC3C=CC=C2C1=3)C(=O)N(CCCN(C)C)C(=O)NCC |&1:0,3,9,r|
CAS Datenbank
81409-90-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36/37
WGK Germany  3
RTECS-Nr. KE6167600
HS Code  2939690000
Toxizit?t Sol in ethyl alcohol, chloroform, DMF; slightly sol in 0.1 N HCl; very slightly sol in n-hexane. Insol in water. LD50 orally in male mice: >400 mg/kg (Brambilla)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Cabergoline Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cabergoline is a potent, selective, and long-lasting dopamine D2 receptor agonist launched in 1993 in Belgium as a prolactin inhibitor. A single 1 mg dose of cabergoline effectively prevents puerperal lactation for up to 14 days, remarkably superior to other drugs that require a daily regimen. It has a low rate of rebound breast activity and good tolerability. Cabergoline is also in clinical trials for Parkinson's disease, breast cancer, and hyperprolactinaemia.

Chemische Eigenschaften

White Crystalline Solid

Verwenden

Cabergoline is an ergot derivative and a dopamine D2-receptor agonist (1,2,3). It inhibits the secretion of prolactin and growth hormone.

Definition

ChEBI: An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substit ted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.

Allgemeine Beschreibung

Cabergoline, (6aR,9R,10aR)-7-allyl-N-(3-(dimethylamino)propyl)-N-(ethylcarbamoyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide (Dostinex), is a white powder soluble inalcohol, chloroform, and N,N-dimethylformamide; slightlysoluble in acidic solutions and in n-hexane; and insoluble inwater. Following oral administration, peak plasma concentrationsare reached within 2 to 3 hours. Cabergoline ismoderately bound to plasma proteins in a concentrationindependentmanner. The absolute bioavailability of cabergolineis unknown. Cabergoline is extensively metabolizedby the liver, predominantly via hydrolysis of the acylureabond of the urea moiety. CYP450 metabolism appears to beminimal. The major metabolites identified thus far do not contribute to the therapeutic effect of cabergoline. Lessthan 4% is excreted unchanged in the urine. Fecal excretionrepresents the main route of cabergoline elimination. Thereare no reports of interactions of cabergoline with other antiparkinsonianagents. Clarithromycin may elevate theplasma concentration of cabergoline by the inhibition ofboth CYP3A4 and P-glycoprotein.Cabergoline is a potentD2 receptor agonist and is indicated for the treatment ofhyperprolactinemic disorders, either idiopathic or causedby pituitary adenomas.

Biologische Aktivit?t

Selective D 2 -like dopamine receptor agonist (K i values are 0.7, 1.5, 9.0 and 165 nM for D 2 , D 3 , D 4 and D 5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K i = 1.2-20.0 nM for 5-HT 1A , 5-HT 1D , 5-HT 2A and 5-HT 2B ). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.

Cabergoline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cabergoline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 335)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Demeikai Biotechnology Co., Ltd
+8618942921723
info@dmksw.xin China 717 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9312 58
HEBEI Meijinnong Import And Export Trade Co.,LTD
+8617363028569
admin@mjn-cn.com China 78 58
Wuhan senwayer century chemical Co.,Ltd
+undefined-27-86652399 +undefined13627115097
market02@senwayer.com China 904 58
Hebei Ningnan Trade Co. LTD
+86-18034019111
admin@hbningnan.com China 255 58
Hebei Shengyuan Jinlong Import and Export Co. LTD
+8617367750398
info@hebeisyjl.com China 1838 58
Anhui Yisheng Technology Co., LTD
+86-19355901310 +86-19355901310
alice@ah-yisheng.com China 319 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
sales03@chemcn.cn China 970 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hong Kong Excellence Biotechnology Co., Ltd.

ada@sh-teruiop.com China 875 58

81409-90-7()Verwandte Suche:


  • 6-allyl-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)ergoline-8-carboxamide
  • CABERGOLINE
  • (8b)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)- ergoline-8-carboxamide
  • Cabaser
  • Dostine
  • FCE-21336
  • C08187
  • Ergoline-8-carboxamide, N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-, (8β)-
  • Galastop
  • Sogilen
  • ((8 )-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)-ergoline-8-carboxamide
  • (8-beta)-(2-propenyl)
  • n-(3-(dimethylamino)propyl)-n-((ethylamino)carbonyl)-6-ergoline-8-carboxamid
  • FCE-21336,Cabaser,Dostinex
  • (8β)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)earbonyl]-6-(2-propenyl)ergoline-8-carboxamide
  • (8R)-6-(2-Propenyl)-8-[[(ethylaminocarbonyl)[3-(dimethylamino)propyl]amino]carbonyl]ergoline
  • N-(Ethylcarbamoyl)-N-[3-(dimethylamino)propyl]-6-allylergoline-8β-carboxamide
  • N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8β-carboxamide
  • Cabergoline (125 mg)
  • 1-[(6-Allylergoline-8β-yl)carbonyl]-1-[3-(dimethylamino)-propyl]-3-ethylurea
  • 1-Ethyl-3-(3′-dimethylaminopropyl)-3-(6′-allylergoline-8′β-carbonyl)urea
  • Cabergoline Impurity
  • Ergoline-8-carboxamide, N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)-, (8β)-
  • cabergoline powder E:candyli(at)speedgainpharma(dot)com
  • Cabergoline CRS
  • Maccagorin
  • (8β)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)-Ergoline-8-carboxamide
  • CABERGILINE
  • Cabergoline (Crude)
  • CabergolineQ: What is Cabergoline Q: What is the CAS Number of Cabergoline Q: What is the storage condition of Cabergoline Q: What are the applications of Cabergoline
  • Cabergoline (1084306)
  • Cefetamet HCl
  • Dostinex
  • CG-101
  • cabergoline powder
  • Caber
  • (6aR,9R,10aR)-7-Allyl-N-(3-(dimethylamino)propyl)-N-(ethylcarbamoyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
  • Carmergoline
  • Cabergoline IP/BP/USP
  • Cabergoline 0.25mg Tablets
  • Cabergoline Tablets
  • 81409-90-7
  • C26H37N5O2
  • API
  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • PP
  • 81409-90-7
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