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Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester

Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester Struktur
168958-19-8
CAS-Nr.
168958-19-8
Englisch Name:
Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester
Synonyma:
Peramivir Impurity 37;(1R,4R)-methyl 4-(tert-butoxycarbonylamino)cyclopent-2-enecarboxylate;Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester;2-Cyclopentene-1-carboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester, (1R,4R)-
CBNumber:
CB02729183
Summenformel:
C12H19NO4
Molgewicht:
241.28
MOL-Datei:
168958-19-8.mol

Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester Eigenschaften

Siedepunkt:
331.2±42.0 °C(Predicted)
Dichte
1.10±0.1 g/cm3(Predicted)
L?slichkeit
soluble in Methanol
pka
11.75±0.40(Predicted)

Sicherheit

Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate in synthesizing trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 26)Lieferanten
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  • Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester
  • (1R,4R)-methyl 4-(tert-butoxycarbonylamino)cyclopent-2-enecarboxylate
  • Peramivir Impurity 37
  • 2-Cyclopentene-1-carboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester, (1R,4R)-
  • 168958-19-8
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