NERIDRONATE SODIUM HYDRATE
|
|
|
- CAS-Nr.
- 79778-41-9
- Englisch Name:
- NERIDRONATE SODIUM HYDRATE
- Synonyma:
- NERIXIA;Neridronic;NERIDRONATE;NERIDRONIC ACID;NERIDRONATE SODIUM HYDRATE;Neridronate >=97% (NMR), solid;Neridronate
DISCONTINUED, offer N390025;6-amino-1-hydroxyhexane-1,1-diphosphonate;6-amino-1-hydroxyhexane-1,1-diphosphonic acid;6-AMINO-1-HYDROXYHEXYLIDENE BISPHOSPHONIC ACID
- CBNumber:
- CB0261270
- Summenformel:
- C6H17NO7P2
- Molgewicht:
- 277.15
- MOL-Datei:
- 79778-41-9.mol
|
NERIDRONATE SODIUM HYDRATE Eigenschaften
- Schmelzpunkt:
- 245°
- Siedepunkt:
- 600.1±65.0 °C(Predicted)
- Dichte
- 1.658±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: 8 mg/mL, soluble
- Aggregatzustand
- solid
- pka
- 1.93±0.10(Predicted)
- Farbe
- white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
|
|
| R-S?tze: |
22 |
|
|
| WGK Germany |
3 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
NERIDRONATE SODIUM HYDRATE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
Beschreibung
Neridronic acid was launched in Italy as intravenous or intramuscular injection for the
treatment of osteogenesis imperfecta. It is the first drug launched worldwide for this
“orphan disease” characterized by a fragility of the bone. Sufferers risk frequent fractures
commencing during infancy, eventually leading to bone deformation and a severe
deterioration of the quality of life and life expectancy. Neridronic acid is structurally related
to the second generation of bisphosphonates characterized by an amino terminal group
and can be synthesized by treating E-aminocaproic acid with phosphoric acid and
phosphorous trichloride. Bisphosphonates, synthetic analogs of the endogenous mineral
deposition inhibitor pyrophosphate, are extremely potent inhibitors of bone resorption and
increase bone mineral density, possibly by inhibiting the activity of osteoclasts and
promoting the death of these bone-eroding cells. In vitro, neridronic acid was a poor
inhibitor of phagocytosis, but significantly and dose dependently inhibited 8glucuronidase
release and superoxide anion production in the rat peritoneal macrophage, two parameters
that may have a part in bone resorption. In a clinical study on patients with osteogenesis
imperfecta, neridronic acid increased remarkably bone mass in young growing individuals.
In adults the changes were less important but still significant.
NERIDRONATE SODIUM HYDRATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NERIDRONATE SODIUM HYDRATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 58)Lieferanten
79778-41-9()Verwandte Suche:
- NERIXIA
- NERIDRONATE
- NERIDRONATE SODIUM HYDRATE
- NERIDRONIC ACID
- 6-AMINO-1-HYDROXYHEXYLIDENE BISPHOSPHONIC ACID
- 6-amino-1-hydroxyhexane-1,1-diphosphonate
- Neridronic
- 6-Amino-1-hydroxyhexylidene bisphosphonic acid, Neridronic acid, Nerixia
- (6-AMino-1-hydroxyhexane-1,1-diyl)diphosphonic acid
- Phosphonic acid,P,P'-(6-aMino-1-hydroxyhexylidene)bis-
- Neridronate
DISCONTINUED, offer N390025
- Neridronate >=97% (NMR), solid
- 6-amino-1-hydroxyhexane-1,1-diphosphonic acid
- (6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid)
- 79778-41-9
- C6H17NO7P2
