Pyridoxal-5'-(dihydrogenphosphat) Chemische Eigenschaften,Einsatz,Produktion Methoden

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Chemische Eigenschaften

Pyridoxal phosphate is a white, odourless crystalline powder that turns bright yellow in alkaline solutions. Its aqueous solution remains stable at low temperatures and in the absence of light but decomposes gradually when exposed to light. It is soluble in formic acid, aqueous pyridine, and dilute alkaline solutions, with limited solubility in organic solvents such as water, ethanol, acetone, chloroform, and ether. The oral LD50 in rats is 5900 mg/kg.

Verwenden

Vitamin (enzyme co-factor).

Definition

Pyridoxal Phosphate also known as PLP, pyridoxal 5'-phosphate or P5P, is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.

synthetische

Synthesis of Pyridoxal Phosphate: Pyridoxal phosphate is synthesized from pyridoxine. Initially, pyridoxamine dihydrochloride is reacted with anhydrous phosphoric acid to produce pyridoxamine phosphate. This intermediate is then oxidized with manganese dioxide to yield pyridoxal phosphate.

l?uterung methode

PLP has been purified by dissolving 2g in H2O (10-15mL, in a dialysis bag a third full) and dialysing with gentle stirring against 1L of H2O (+ two drops of toluene) for 15hours in a cold room. The dialysate is evaporated to 80-100mL, then lyophilised. Lemon yellow microscopic needles of the monohydrate remain when all the ice crystals have been removed. The purity is checked by paper chromatography (in EtOH or n-PrOH/NH3) and the spot(s) visualised under UV light after reaction with a spray of p-phenylene diamine, NH3 and molybdate. Solutions stored in a freezer are 2-3% hydrolysed in 3weeks. At 25o, only 4-6% hydrolysis occurs even in N NaOH or HCl, and 2% is hydrolysed at 37o in 1day-but is complete at 100o in 4hours. It is best stored as a dry solid at -20o. In aqueous acid the solution is colourless but is yellow in alkaline solutions. It has UV max at 305nm ( 1100) and 380nm ( 6550) in 0.1 N NaOH; 330nm ( 2450) and 388nm ( 4,900) in 0.05M phosphate buffer pH 7.0 and 295nm ( 6700) in 0.1N HCl. [Peterson et al. Biochemical Preparations 3 34, 119 1953.] The oxime decomposes at 229-230o and is practically insoluble in H2O, EtOH and Et2O. The O-methyloxime decomposes at 212-213o. [Heyl et al. J Am Chem Soc 73 3430 1951.] It has also been purified by column chromatography through Amberlite IRC-50 (H+) [Peterson & Sober J Am Chem Soc 76 169 1954]. [Beilstein 21/13 V 46.]

Pyridoxal-5'-(dihydrogenphosphat) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pyridoxal-5'-(dihydrogenphosphat) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shaanxi LonierHerb Bio Technology Co Ltd	+86-86-+86-86-029-87551862 +8617702909819	sales006@ingredients-lonier.com	China	2608	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18151	58
Wuhan Haorong Biotechnology Co.,ltd	+86-18565342920; +8618565342920	sales@chembj.net	China	289	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	423	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+8615350851019	admin@86-ss.com	China	1001	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55

54-47-7(Pyridoxal-5'-(dihydrogenphosphat))Verwandte Suche:

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• Pyridoxal 5'-(dihydrogen phosphate)
• Pyridoxal phosphate
• Codecarboxylase PLP
• 2-Methyl-3-hydroxy-4-formyl-5-pyridylmethylphosphoric acid
• 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate
• 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-
• Coenzyme B6
• Pydoxa
• Aderol
• Navisal
• Neoaderol
• Pyridoxal-5-phosphate(P5P)
• 3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde
• P-5-P
• (4-formyl-5-hydroxy-6-methyl-pyridin-3-yl)methoxyphosphonic acid
• PYRIDOXAL-5-PHOSPHORIC ACID
• CODECARBOXYLASE
• 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinecarboxaldehyd
• 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyd
• apolonb(sub6)
• apolonb6
• biosechs
• hairoxal
• hexerminp
• hiadelon
• hi-pyridoxin
• pal-p
• phosphopyridoxal
• phosphoridoxalcoenzyme
• piodel
• pydoxal
• pyridoxaldehydephosphate
• pyridoxalmonophosphate
• pyridoxalp
• pyridoxylphosphate
• pyromijin
• sechvitan
• vitahexinp
• vitazechs
• PYRIDOXAL-5-PHOSPHATE(P)
• (3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methyl phosphate
• Pyridoxal-5'-Phosphate~99%
• Pyridoxal-5-Phosphate99.0%Min.
• VitaminB6phosphate
• Pyridoxal 5-phosphate (methyl-D3)
• Pyridoxal phosphate（PLP）
• 5-Pyridoxal phosphate
• Pyridoxal phosphate USP/EP/BP
• Pyridoxal phosphate/P5P
• Pyridoxal phosphate API
• PYRIDOXINEPHOSPHATE
• Pyridoxal-5-phosphat
• PYRIDOXAL 5'-MONOPHOSPHATE
• Pyridoxal5′-phosphate 5
• Pyridoxal 5'-phosphate(P5P)
• Cymoxanil Impurity 1
• Pyridoxal 5-Phosphate in Water:Acetonitrile=8:2
• 54-47-7