Danoprevir
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- CAS-Nr.
- 850876-88-9
- Englisch Name:
- Danoprevir
- Synonyma:
- Danoprevir;RG7227;Intepirdine;R7227;CS-64;RG72277;ITMN-191;RO5190591;Danpprevir;Danoprevir, >=98%
- CBNumber:
- CB02504568
- Summenformel:
- C35H46FN5O9S
- Molgewicht:
- 731.83
- MOL-Datei:
- 850876-88-9.mol
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Danoprevir Eigenschaften
- Schmelzpunkt:
- >165°C (dec.)
- Dichte
- 1.41
- storage temp.
- -20°C Freezer
- L?slichkeit
- Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 4.43±0.60(Predicted)
- Farbe
- White to Pale Beige
- InChIKey
- ZVTDLPBHTSMEJZ-AIYSODCISA-N
- SMILES
- C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O |t:33|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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Sicherheit |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Danoprevir Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC
50 = 1 nM), a serine protease essential for HCV replication. It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC
50s = 0.2-0.4 nM) as well as 2b and 3a (IC
50s = 1.6 and 3.5 nM, respectively)
in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC
50 = 1.8 nM).
Verwenden
Danoprevir is a selective and potent inhibitor of Hepatitis C virus.
Danoprevir Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Danoprevir Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 112)Lieferanten
- RG7227, ITMN-191, RO5190591
- 4-Fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
- ITMN-191
- Danoprevir(ITMN-191)
- 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
- dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester Danoprevir (ITMN-191)
- Danoprevir, >=98%
- Itmn-191 Danoprevir
- (2R,6S,13aS,14aR,16aS,E)-6-((tert-butoxycarbonyl)aMino)-14a-((cyclopropylsulfonyl)carbaMoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
- R7227
- RO5190591
- Danoprevir (RG7227)
- Danoprevir(ITMN-191, RG7227)
- Danoprevir - ITMN 191 | RG 7227 | R 7227
- 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dio
- CS-64
- ITMN-191; R7227; RO5190591; RG7227;ITMN191;ITMN 191
- (2R,6S,13aS,14aR,16aS,)-6-((tert-Butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
- RG72277
- (2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
- Danpprevir
- Danoprevir ( ITMN191, R7227
- Intepirdine
- RG7227
- Danoprevir
- Danoprevir ITMN-191 Selleck HCV Protease inhibitor
- Danoprevir(ITMN-191)/RG7227,RO5190591
- (2R,6S,13aS,14aR,16aS,Z)-6-((tert-Butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyc
- 850876-88-9
- Inhibitor
- Inhibitors
- Coronavirus