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4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-

4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Struktur
663619-89-4
CAS-Nr.
663619-89-4
Englisch Name:
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-
Synonyma:
CS-429;TGX 221;TGX-221; TGX 221;TGX221; TGX221; TGX 221.;PI 3-Kβ Inhibitor VI, TGX-221;TGX-221 PI3K inhibitor ab120924;TGX-221, PI3K Inhibitor (±9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one;7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one;(+/-)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one
CBNumber:
CB02456412
Summenformel:
C21H24N4O2
Molgewicht:
364.44
MOL-Datei:
663619-89-4.mol

4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Eigenschaften

Schmelzpunkt:
198-201oC
Siedepunkt:
557.3±60.0 °C(Predicted)
Dichte
1.25±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
L?slichkeit
DMSO (Slightly), Methanol (Very Slightly)
pka
3.90±0.50(Predicted)
Aggregatzustand
Pale yellow solid.
Farbe
Off-White to Pale Yellow

Sicherheit

4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

TGX-221 is a potent, selective, and cell permeable inhibitor of Phosphatidylinositol 3-kinase (PI3K) p110β.

Allgemeine Beschreibung

A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC50 = 0.005, 0.1, 5, and ≥3.5 μM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 μM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.

Biochem/physiol Actions

Cell permeable: yes

4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 145)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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Biochempartner 		0086-13720134139
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Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
  • 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-
  • TGX 221
  • (+/-)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one
  • 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one
  • (+/-)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one TGX 221
  • TGX 221 (+/-)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one
  • PI 3-Kβ Inhibitor VI, TGX-221
  • CS-429
  • TGX-221; TGX 221
  • TGX-221, PI3K Inhibitor (±
  • TGX221; TGX221; TGX 221.
  • 9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
  • 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- ISO 9001：2015 REACH
  • TGX-221 PI3K inhibitor ab120924
  • 663619-89-4
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
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