Albendazole
|
|
Albendazole Eigenschaften
- Schmelzpunkt:
- 208-210 °C
- Dichte
- 1.2561 (rough estimate)
- Brechungsindex
- 1.6740 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- Practically insoluble in water, freely soluble in anhydrous formic acid, very slightly soluble in methylene chloride, practically insoluble in ethanol (96 per cent).
- Aggregatzustand
- Solid
- pka
- 10.72±0.10(Predicted)
- Farbe
- White to Off-White
- Wasserl?slichkeit
- 0.75mg/L(209 ºC)
- Merck
- 14,210
- BCS Class
- 4
- InChI
- InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
- InChIKey
- HXHWSAZORRCQMX-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)NC1NC2=CC(SCCC)=CC=C2N=1
- CAS Datenbank
- 54965-21-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T,Xn | ||
---|---|---|---|
R-S?tze: | 61-36/37/38-48/22-63-33 | ||
S-S?tze: | 53-45-37/39-26-36/37-24/25 | ||
WGK Germany | 2 | ||
RTECS-Nr. | FD1100000 | ||
HS Code | 29332990 | ||
Giftige Stoffe Daten | 54965-21-8(Hazardous Substances Data) |
Bildanzeige (GHS) |
![]() ![]() |
|||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alarmwort | Warnung | |||||||||||||||||||||
Gefahrenhinweise |
|
|||||||||||||||||||||
Sicherheit |
|
Albendazole Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R61:Kann das Kind im Mutterleib sch?digen.R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Albendazole occurs as a white to faintly yellowish powder. It is practically insoluble in water and alcohol, very slightly soluble in ether and dichloromethane, but freely soluble in anhydrous formic acid.Verwenden
Albendazole is a derivative of benzimidazole, is a drug with a broad antihelmintic spectrum. It exhibits an antihelmintic effect against sensitive cestodes and nematodes by blocking the process of glucose uptake by the parasites, which is expressed in the depletion of glycogen reserves and subsequent reduction in the level of adenosintriphophate. As a result, the parasite stops moving and dies. It is used upon infection of Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, and Trichuris trichiura. Synonyms of this drug are SKF 62979 and others.Indications
Albendazole appears to cause cytoplasmic microtubular degeneration, which in turn impairs vital cellular processes and leads to parasite death.There is some evidence that the drug also inhibits helminth-specific ATP generation by fumarate reductase.Antimicrobial activity
Albendazole is active against trichostrongyles and exhibits useful activity against tissue-dwelling larvae of Trichinella spiralis, larvae of animal hookworms (causing cutaneous larva migrans) and microfilariae of various filarial species. It also exhibits some activity against cysticercosis and hydatid stages of Echinococcus granulosus and Echinococcus multilocularis. It has been successfully used in infections with the protozoon Giardia lamblia and for microsporidiosis.Allgemeine Beschreibung
Albendazole occurs as a white crystalline powder that isvirtually insoluble in water. The oral absorption of albendazoleis enhanced by a fatty meal. The drug undergoes rapidand extensive first-pass metabolism to the sulfoxide, whichis the active form in plasma. The elimination half-life ofthe sulfoxide ranges from 10 to 15 hours. Considerable biliaryexcretion and enterohepatic recycling of albendazolesulfoxide occurs. Albendazole is generally well toleratedin single-dose therapy for intestinal nematodes. The highdose,prolonged therapy required for clonorchiasis orechinococcal disease therapy can result in adverse effectssuch as bone marrow depression, elevation of hepatic enzymes,and alopecia.Mechanism of action
Albendazole is given orally and is poorly and variably absorbed (5%) because of its poor water solubility. Oral bioavailability is increased as much as five times when the drug is given with a fatty meal instead of on an empty stomach. Concurrent treatment with corticosteroids increases plasma concentrations of albendazole. The drug is rapidly metabolized in the liver to an active sulfoxide metabolite.The half life of the metabolites is 8 to 12 hours.Pharmakokinetik
Albendazole is better absorbed after oral absorption than other benzimidazole carbamates. It is extensively metabolized to the anthelmintically active albendazole sulfoxide, producing plasma concentrations of the metabolite of about 1.3 mg/L 2–5 h after a 400 mg oral dose. The half-life is about 8 h and the major route of excretion is via the bile. Plasma protein binding of the sulfoxide is around 70%.Clinical Use
Albendazole has a broad spectrum of activity against intestinal nematodes and cestodes, as well as the liver flukes Opisthorchis sinensis, Opisthorchis viverrini, and Clonorchis sinensis. It also has been used successfully against Giardia lamblia. It is widely used throughout the world for the treatment of intestinalnematode infection. It is effective as a single-dose treatmentfor ascariasis, New and Old World hookworm infections,and trichuriasis. Multiple-dose therapy with albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis,and hydatid disease. The effectiveness of albendazole againsttapeworms (cestodes) is generally more variable and lessimpressive. It also is effective in treating cerebral and spinal neurocysticercosis, particularly when given with dexamethasone.Albendazole is recommended for treatment of gnathostomiasis.Nebenwirkungen
Various mild intestinal and other upsets usually resolve without treatment. With extended use, as for larval tapeworm infections, hepatic abnormalities or leukopenia may require discontinuation of treatment. In rare cases granulocytopenia, pancytopenia, agranulocytosis or thrombocytopenia may occur. It should not be given during pregnancy since it may cause fetal harm; women should be cautioned against becoming pregnant within a month of completing treatment.Albendazole Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Cyanamide Methyl
Zink
4-Amino-3-nitrophenylthiocyanat
1-Chlor-4-nitrobenzol
Ethanol
Tetrabutylammoniumbromid
Dinatriumsulfid
Natriumthiocyanat
Carbendazim
Ammoniumthiocyanat
Aluminium
Chloroschwefelsure
Nitroanilin (o,m,p)
1-Propanthiol
Sulfuryldichlorid
Essigsure
Natriumhydroxid
Eisen
1-Brompropan
Senf?l
ERYTHORMYCIN THIOCYANATE
Cyanamid
Wasserstoff
Methyl-chlorformiat
Downstream Produkte
Albendazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 998)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 |
mack@tongyon.com | China | 2994 | 58 |
Hebei ZB Gamay Biological Technology Co.,Ltd | +8617330018573 |
info@zbvet.net | China | 248 | 58 |
Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085 +86-15531157085 |
abby@chuanghaibio.com | China | 8807 | 58 |
Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 |
3684455296@qq.com | China | 9300 | 58 |
Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 +86-15350571055 |
Sibel@chuanghaibio.com | China | 6087 | 58 |
HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 |
L18532138899@163.com | China | 939 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5969 | 58 |
Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 |
sales1@hbganmiao.com | China | 227 | 58 |
shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 |
sales@sdperfect.com | China | 294 | 58 |
Wuhan Han Sheng New Material Technology Co.,Ltd | +8617798174412 |
admin01@hsnm.com.cn | China | 2097 | 58 |
54965-21-8()Verwandte Suche:
Imidazol
Methylacetat
Methylthenoat
Bensulfuron methyl
Methyl-4-hydroxybenzoat
Methylanthranilat
Methylacrylat
Kresoxim-methyl
Thiamazol
Phenformin
N-Cyclohexylsulfamidsure
Benzimidazol
Melassen
Thiophanat-methyl
Methyl
Parathion-methyl (ISO)
Brommethan
Calciumcyanamid
- [5-(PROPYLTHIO)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER
- (5-PROPYLSULFANYL-1H-BENZOIMIDAZOL-2-YL)-CARBAMIC ACID METHYL ESTER
- ALBAZINE
- ALBENDAZOLE
- AKOS NCG1-0064
- METHYL 5-(PROPYLTHIO)-2-BENZIMIDAZOLECARBAMATE
- METHYL [5-(PROPYLTHIO)BENZIMIDAZOL-2-YL]CARBAMATE
- LABOTEST-BB LT00012679
- ESKAZOLE
- PROFTRIL
- SKF-62979
- ZEBEN
- ZENTAL
- VALBAZENE
- 2-METHOXYCARBONYLAMINO-5-PROPYLTHIO-1H-BENZIMIDAZOLE
- ((propylthio)-51h-benzimidazolyl-2)carbamatedemethyle
- 5-(propylthio)-2-carbomethoxyaminobenzimidazole
- Carbamicacid,[5-(propylthio)-1H-benzimidazol-2-yl]-,methylester
- Methyl5-propylthio-2-benzeimidazolecarbamate
- Monil
- METHYL5-PROPYLTHIO-2-BENZIMIDAZOLECARBAMATE(ALBENDAZOLE)
- Albendazole, 98+%
- Azbendazole
- Bilutac
- Albamelin
- Methyl 5-(propylthio)-2-benzimidazolecarbamat
- Albendazole (200 mg)H0E2400.996mg/mg(dr)
- Albendazole (200 mg)
- Andazol
- Ashialben
- Bruzol
- N-[6-(Propylthio)-1H-benziMidazol-2-yl]carbaMic Acid Methyl Ester
- Albendazole COS
- Methyl [5-(Propylthio)benzimidazol-2-yl]carbamate [5-(Propylthio)benzimidazol-2-yl]carbamic Acid Methyl Ester
- N-(5-Propylthio-1H-benzimidazol-2-yl)carbamic acid methyl ester
- Methyl 5-propylthio-2-benzimidazolecarbamate,98%
- (5-(propylthio)-1h-benzimidazol-2-yl)-carbamicacimethylester
- Albendazole Crude
- ALBENDAZOLE CP 2000
- ALBENDAZOLE USP24 AND CP2000
- [5-(Propylthio)-1H-benzimidazol-2-yl]carbamic Acid, Methyl Ester, SKF-62979, Albenza, Eskazole, Proftril, Valbazen, Zentel
- ALBENDAZOLEWHITE99%
- ALBENDAZOLE,USP
- ALBENDAZOLE CP 95 ,USP 26, EP 4
- Methyl N-[5-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbaMate
- ALBENDAZOLE WHITE
- ALBENDAZOLE, PHARMA
- ALBENDAZOLE CP
- Albendazole , 98.0%(N)
- albendazole Solution, 100ppm
- albendazloe
- AlbendazAlbendazolezoleAlbendazAlbendazolezole
- Albendazole powder
- lbendazole
- Albendazole Zentel
- Albendazole Manufacturer
- Albendazole for system suitability
- Albendazole Solution, 1000ppm