N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
|
|
|
- CAS-Nr.
- 136132-67-7
- Englisch Name:
- N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
- Synonyma:
- CPSB;CTSB;z-rr-amc;APP secretase;Z-RR-AMC, 2HCL;Z-ARG-ARG-MCA.HCL;Z-ARG-ARG-AMC 2HCL;Z-Arg-Arg-AMC/Z-RR-AMC;Cathepsin B Active human;Z-ARG-ARG-MCA HYDROCHLORIDE
- CBNumber:
- CB0188887
- Summenformel:
- C30H40ClN9O6
- Molgewicht:
- 658.15
- MOL-Datei:
- 136132-67-7.mol
|
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Eigenschaften
- storage temp.
- -20°C
- Aggregatzustand
- aqueous solution
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
|
|
| R-S?tze: |
36/37/38 |
|
|
| S-S?tze: |
26-36 |
|
|
| WGK Germany |
3 |
|
|
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
|
| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
|
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:
- as a cathepsin B substrate in zymography analysis of protease in feces extract.
- in cathepsin B activity assay.
- as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.
Allgemeine Beschreibung
Human cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide(amino acids 1-16) + Cathepsin B (amino acids 18-339), with C-terminal HIS tag, MW = 43 kDa, expressed in FreeStyle 293-F cells. Cathepsin B is a cysteine protease, found in the lysosome of normal cells and tissues. Cathepsin B active human is encoded by the gene CTSB, located on human chromosome 8p23.1.
Biochem/physiol Actions
Cathepsin B Active human primarily is a preproenzyme, glycosylated on rough endoplasmic reticulum. Processing of procathepsin B to a 31 kDa, single chain active form occurs in the lysosome. It is further processed to double chain form with a 25/26 kDa heavy chain and 5 kDa heavy chain in lysosome. Cathepsin B, functions as an exopeptidase at low pH. At higher pH in endosomes or neutral pH, cathepsin B functions as endopeptidase. Cathepsin B expression is upregulated in malignant tumors and facilitates tumor invasion. Cathepsin B might reduce the production of amyloid-β peptide associated with Alzheimerβs disease. It also plays a key role in neuroprotective functions.
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 65)Lieferanten
136132-67-7()Verwandte Suche:
- N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
- Z-ARG-ARG-7-AMIDO-4-METHYL COUMARIN, DIHCL
- Z-ARG-ARG-AMC 2HCL
- Z-ARG-ARG-AMC HYDROCHLORIDE SALT
- Z-ARG-ARG-MCA HYDROCHLORIDE
- Z-ARG-ARG-MCA(HYDROCHLORIDE FORM)
- Z-L-ARGINYL-L-ARGININE-7-AMIDO-4-METHYLCOUMARIN 2HCL
- Z-RR-AMC, 2HCL
- z-arg-arg-7-amido-4-methylcoumarin hydrochloride
- z-rr-amc
- Z-ARG-ARG-MCA.HCL
- ANTI-CATB (CENTER) antibody produced in rabbit
- APP secretase
- CPSB
- CTSB
- Cathepsin B Active human
- BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE
- CATHEPSIN B SUBSTRATE III, FLUOROGENIC
- CATHEPSIN B SUBSTRATE IV, FLUOROGENIC
- na-cbz-arg-arg 7-amido-4-methylcoumarin hydrochlo
- NA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORI
- N-CBZ-ILE-GLU-THR-ASP-7-AMINO-4- TRIFLUO ROMETHYLCOU
- Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,Z-RR-AMC
- Z-Arg-Arg-AMC/Z-RR-AMC
- N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE USP/EP/BP
- Recombinant Mouse Cathepsin B/Ctsb Protein, His Tag
- Recombinant Human Cathepsin B/CTSB Protein, His Tag
- Z-Arg-Arg-7-amido-4-methylcoumarin
- CBZ-Arg-Arg-7-amido-4-methylcoumarin hydrochloride
- Z-Arg-Arg-AMC hydrochloride
- Mouse Anti-Caspase 8 antibody
- 136132-67-7
- C30H39N9O6
- C30H41Cl2N9O6
- C30H39N9O6HCl
- Cathepsins and Granzymes
- Cathepsin B
- Caspases
- Caspase 8
- Cell Signaling and Neuroscience
- Cell Biology
- Apoptosis and Cell Cycle
- BioChemical
- Substrates
- Substrates
