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NVP-BEZ 235

NVP-BEZ 235 Struktur
915019-65-7
CAS-Nr.
915019-65-7
Englisch Name:
NVP-BEZ 235
Synonyma:
104794;CS-381;BEZ-235;Dactolisib;NVP-BEZ 235;BEZ235 0.6G;BEZ235, >=98%;NVP-BEZ235(BEZ235);BEZ235 (NVP-BEZ235);Dactolisib (BEZ235)
CBNumber:
CB01872365
Summenformel:
C30H23N5O
Molgewicht:
469.55
MOL-Datei:
915019-65-7.mol

NVP-BEZ 235 Eigenschaften

Schmelzpunkt:
288-289°C
Siedepunkt:
701.0±70.0 °C(Predicted)
Dichte
1.299
storage temp. 
Refrigerator
L?slichkeit
Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75?C).
pka
6.41±0.20(Predicted)
Aggregatzustand
White powder.
Farbe
White or off-white
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
CAS Datenbank
915019-65-7
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

NVP-BEZ 235 Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Light Beige Solid

Verwenden

Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR.

Definition

ChEBI: An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.

in vivo

BEZ235 induced tumor regression (69%) without a statistically significant effect on weight gain. Taken together, these preliminary in vivo efficacy findings suggest that BEZ235 blocks disease progression when administered orally alone and enhances efficacy when combined with other anticancer drugs.

NVP-BEZ 235 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NVP-BEZ 235 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 219)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21639 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070
product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32820 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29886 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 965 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58

915019-65-7()Verwandte Suche:

  • 4-[2,3-Dihydro-3-Methyl-2-oxo-8-(quinolin-3-yl)-1H-iMidazo[4,5-c]quinolin-1-yl]-alpha,alpha-diMethylbenzeneacetonitrile
  • BEZ-235
  • 2-methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile
  • 2-Methyl-2-[3-Methyl-2-oxo-8-(3-quinolinyl)-1-iMidazo[4,5-c]quinolinyl]propanenitrile
  • BEZ235 (NVP-BEZ235, Dactolisib)
  • 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl
  • BEZ235 NVP-BEZ235(BEZ235)
  • Dactolisib
  • 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile BEZ235(NVP-BEZ235)
  • NVP-BEZ 235 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile
  • Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-.alpha.,.alpha.-dimethyl-
  • 4-[2,3-Dihydro-3-Methyl-2-oxo-8-(3-quinolinyl)-1H-iMidazo[4,5-c]quinolin-1-yl]-α,α-diMethyl-benzeneacetonitrile
  • NVP-BEZ235(BEZ235)
  • BEZ235, >=98%
  • BEZ-235 (Dactolisib)
  • 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile Dactolisib
  • 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phe
  • NVP-BEZ 235
  • 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile
  • 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
  • BEZ235 0.6G
  • BEZ235 (NVP-BEZ235)
  • 104794
  • Dactolisib (BEZ235, NVP-BEZ235)
  • CS-381
  • Dactolisib (BEZ235)
  • NVP-BEZ235(Dactolisib
  • NVP-BEZ 235;BEZ-235;BEZ 235;NVP-BEZ235;DACTOLISIB
  • Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-
  • NVP-BEZ 235 USP/EP/BP
  • TIANFU-CHEM BEZ235 (NVP-BEZ235, Dactolisib)
  • Dactolisib(NVP-BEZ 235)
  • 4-2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo4,5-cquinolin-1-yl-.alpha.,.alpha.-dimethyl-benzeneacetonitrile
  • 915019-65-7
  • 5019-65-7
  • C30H23N5O
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators
  • api
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
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