Bimatoprost
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- CAS-Nr.
- 155206-00-1
- Englisch Name:
- Bimatoprost
- Synonyma:
- Bima;LUMIGAN;bimatoprost powder;N-ETHYL-9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z, 13E-DIEN-1-AMIDE;bimatopros;Bimatoprost (W.S);BiMatoprost HOUSE STANDARD;17-phenyl-tri-norprostaglandin f2α-ethyl amide;17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ETHYL AMIDE;CS-2897
- CBNumber:
- CB0171421
- Summenformel:
- C25H37NO4
- Molgewicht:
- 415.57
- MOL-Datei:
- 155206-00-1.mol
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Bimatoprost Eigenschaften
- Schmelzpunkt:
- 66-68°C
- Siedepunkt:
- 629.8±55.0 °C(Predicted)
- Dichte
- 1.145±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
- Aggregatzustand
- solid
- pka
- 14.25±0.20(Predicted)
- Farbe
- White to Off-White
- BCS Class
- 3
- Stabilit?t:
- Light Sensitive
- InChIKey
- AQOKCDNYWBIDND-FTOWTWDKSA-N
- SMILES
- C(NCC)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCC1=CC=CC=C1
- CAS Datenbank
- 155206-00-1(CAS DataBase Reference)
Bimatoprost Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Bimatoprost was first introduced in the US and Brazil as Lumigan?, an ophthalmic
solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with
open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field
loss. Bitamoprost is a new agent belonging to the PGF
2α analog class of prostamides
launched in this indication after latanoprost, the most efficaceous topical medication
currently available. This synthetic fatty acid amide can be prepared by esterification of 17-
phenyl-18,19,20-trinorprostaglandin F
2α followed by ethylamidation. Bimatoprost, as related
prostamides, is devoid of typical activities associated with PGF2,, analogs; it exhibits a
unique pharmacological profile in contracting the feline iris sphincter with an EC
50 of 34 nM
without interacting with any known prostanoid receptors. Thus it mimics the action of
endogenous prostamides on specific receptors that lower IOP by increasing aqueous
humor outflow through both pressure-insensitive and pressure-sensitive pathways without
reducing humor formation. In a 3-month controlled clinical trial of efficacy and safety in patients with elevated IOP, bimatoprost demonstrated lower mean intraocular pressures at
every time point throughout the study, as well as a good tolerance and systemic safety
profile compared to latanoprost.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha
Allgemeine Beschreibung
Bimatoprost (Lumigan) is supplied as a sterile 0.03%ophthalmic solution in 2.5- and 5.0-mL sizes. The recommendeddosage of bimatoprost is limited to one drop intothe affected eye once daily in the evening. Increased usagemay decrease its beneficial effect. If used concurrently withother IOP-lowering drugs, a waiting period of 5 minutesshould separate administrations.
Bimatoprost Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Bimatoprost Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 578)Lieferanten
155206-00-1()Verwandte Suche:
- BIMATOPROST
- BIMATOPROST(TM)
- BIMATOPROST(LUMIGAN)
- (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
- (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenamide
- Prostamide
- 17-phenyl-tri-norprostaglandin f2α-ethyl a
- cGMP Bimatoprost
- BiMapnost
- (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enaMide
- Bimatoprost, >=99.5%
- 17-Phenyl-tri-norprostaglandin F2a-ethyl aMide
- (Z)-7-((1R,2R,3S,5S)-3,5-dihydroxy-2-((E)-3-hydroxy-5-phenylpent-1-enyl)cyclopentyl)-N-ethylhept-5-enamide
- (Z)-7-((1R,2R,3S,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-enyl)cyclopentyl)-N-ethyl
- Bimatoprost API
- Bimatoprost CAS NO.155206-00-1
- buprostaglandin
- Beme Prostaglandin
- CS-2897
- 5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5Z)-
- 17-Phenyltrinor-PGF2alpha Ethylamide
- (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(S,E)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enamide
- Bimatoprost USP/EP/BP
- (Z)-7-[(1S,2S,3R,5R)-3,5-Dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
- Bimatoprost CAS 155206 00 1
- Bimatoprost (AGN 192024)
- BimatoprostQ: What is
Bimatoprost Q: What is the CAS Number of
Bimatoprost Q: What is the storage condition of
Bimatoprost Q: What are the applications of
Bimatoprost
- N-ETHYL-9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z, 13E-DIEN-1-AMIDE
- LUMIGAN
- 17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ETHYL AMIDE
- bimatoprost powder
- Bima
- bimatopros
- 6-Amino-2,4-dichloro-6-methylphenol&hydrochloride
- 17-phenyl-tri-norprostaglandin f2α-ethyl amide
- BiMatoprost HOUSE STANDARD
- Bimatoprost (W.S)
- Bimalprostone
- Bimatoprost-1
- (E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-
hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
- Bimatoprost Reference Standard
- Bisoprostol
- Bimatoprost
CAS
- Hydroxy-5-Phenylpent-1-Enyl]Cyclopentyl]-N-Ethylhept-5-
- Bemeprost
- Bimatoprost, 10 mM in DMSO
- 155206-00-1
- 206-00-1
- Prostaglandin
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Arachidonic Acid Cascade
- Lipids in Cell Signaling
- Prostaglandins
- Lumigan
- Inhibitors
- Benzotriazoles ,Others ,Benzoxazines
