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LAPAQUISTAT

LAPAQUISTAT Struktur
189060-13-7
CAS-Nr.
189060-13-7
Englisch Name:
LAPAQUISTAT
Synonyma:
TAK-475;CS-1400;LAPAQUISTAT;Lapaquistat Acetate;Lapaquistat Acetate (TAK-475);Lapaquistat and Lapaquistat Acetate;1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid;2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid;4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-;2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid
CBNumber:
CB01509119
Summenformel:
C33H41ClN2O9
Molgewicht:
645.14
MOL-Datei:
189060-13-7.mol

LAPAQUISTAT Eigenschaften

Schmelzpunkt:
194-196℃
Siedepunkt:
826.4±65.0 °C(Predicted)
Dichte
1.246±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
4.66±0.10(Predicted)
Farbe
White

Sicherheit

LAPAQUISTAT Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels.Antiarteriosclerotics.

LAPAQUISTAT Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

LAPAQUISTAT Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 29)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Alfa Chemistry
Info@alfa-chemistry.com United States 24072 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
ZHIWE CHEMTECH CO LTD 021-20221225 13917446399
 sales@zhiwe.net China 627 61
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15402 60
Wulechem Co., Ltd. 13761914825
 wulesian@wulechem.com China 297 58
SPIRO PHARMA
eric_feng1954@126.com China 9248 55
Nanjing NingFan Pharm-Tech CO. LTD. 17368696818
China 1984 58
  • LAPAQUISTAT
  • Lapaquistat and Lapaquistat Acetate
  • Lapaquistat Acetate
  • 2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid
  • TAK-475
  • 1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid
  • CS-1400
  • Lapaquistat Acetate (TAK-475)
  • 4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-
  • 2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid
  • 189060-13-7
  • C33H41ClN2O9
  • Amines
  • Chiral Reagents
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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