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Prostratin, PKC activator

Prostratin, PKC activator Struktur
60857-08-1
CAS-Nr.
60857-08-1
Englisch Name:
Prostratin, PKC activator
Synonyma:
SA 101A;NSC 623310;CCRIS 6292;PROSTRATIN;Prostatin >99%;Stillingia Facto;13-O-Acetylphorbol;Prostratin, PKC activator;12-DEOXYPHORBOL 13-ACETATE;13-O-Acetyl-12-deoxyphorbol
CBNumber:
CB0150130
Summenformel:
C22H30O6
Molgewicht:
390.47
MOL-Datei:
60857-08-1.mol

Prostratin, PKC activator Eigenschaften

Schmelzpunkt:
216-219℃
Siedepunkt:
550.5±50.0 °C(Predicted)
Dichte
1.31
storage temp. 
-20°C
L?slichkeit
Soluble in DMSO at 30mg/ml
Aggregatzustand
white powder
pka
11.40±0.70(Predicted)
Farbe
Off-white
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Sicherheit

WGK Germany  3
HS Code  2916200090

Prostratin, PKC activator Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC50 value of ~0.5 μM. Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.

Definition

ChEBI: A natural product found in Euphorbia fischeriana.

Prostratin, PKC activator Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Prostratin, PKC activator Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 63)Lieferanten
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
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60857-08-1()Verwandte Suche:


  • SA 101A
  • Prostatin >99%
  • 12-Deoxyphorbol 13-Acetate, dPAc
  • (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-
  • 13-O-Acetyl-12-deoxyphorbol
  • PROSTRATIN
  • (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl- 5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
  • 13-O-Acetylphorbol
  • NSC 623310
  • Stillingia Facto
  • CCRIS 6292
  • 12-DEOXYPHORBOL 13-ACETATE
  • (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-9aα-acetoxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benzo[1,2-e]azulene-5-one
  • (1aR)-9aα-Acetoxy-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
  • Prostratin, PKC activator
  • 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bR,8R,9aS)-
  • Prostratin, PKC activator USP/EP/BP
  • (1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate
  • 60857-08-1
  • Activator
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators
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