2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol
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- CAS-Nr.
- 128607-22-7
- Englisch Name:
- 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol
- Synonyma:
- Ospemifene;CS-1039;Fc-1271a;Ccris 9205;Ospemifene >Unii-B0p231ilbk;2-(4-(4-chloro-1;Ospemifene FC-1271a;The department of pp meters;2-diphenyl-but-1-enyl)phenoxy)ethanol
- CBNumber:
- CB01335273
- Summenformel:
- C24H23ClO2
- Molgewicht:
- 378.89
- MOL-Datei:
- 128607-22-7.mol
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2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Eigenschaften
- Siedepunkt:
- 544.6±50.0 °C(Predicted)
- Dichte
- 1.166±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMSO: soluble20mg/mL, clear
- Aggregatzustand
- powder
- pka
- 14.26±0.10(Predicted)
- Farbe
- white to beige
- InChIKey
- LUMKNAVTFCDUIE-VHXPQNKSSA-N
- CAS Datenbank
- 128607-22-7
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In February 2013, the US FDA approved ospemifene (also referred to as FC1271a), for the treatment ofmoderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy (VVA), due tomenopause. It is estimated that there are 150 million postmenopausal women worldwide with 40–70% suffering from VVA. Ospemifene is a selective estrogen receptor (ER) modulator (SERM) and the first nonhormonal, nonestrogen for the treatment of moderate to severe dyspareunia in women with menopausal VVA. It binds to ERα (IC
50～800 nM) and ERβ (IC
50～1600 nM) with tissue-specific estrogenic agonist/antagonist effects. Treatment with ospemifene increases the thickness of the vaginal tissue thereby decreasing fragility of the tissue and reducing potential for pain during sexual intercourse.
Verwenden
Treatment of vaginal atrophy, osteoporosis, and vasomotor symptoms.
Definition
ChEBI: An organochlorine compound that is a selective estrogen receptor modulator; used for treatment of dyspareunia.
Clinical Use
Ospemifene is a SERM that is currently in Phase II/III clinical trials for the treatment of postmenopausal
osteoporosis and urogenital atrophy. It is a known metabolite of toremifene, a triphenylethylene
derivative used to treat breast cancer.Ospemifene has been shown to have beneficial effects on the bone
without significant estrogen-related side effects. The beneficial effect observed on bone stems from this
agent's ability to increase osteoblast proliferation and, as a result, to enhance bone mineralization as well as
bone formation. Unlike tamoxifen, ospemifene does not induce osteocyte apoptosis.
2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 152)Lieferanten
- 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol
- 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-ethanol
- 2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol
- Ccris 9205
- Fc-1271a
- Unii-B0p231ilbk
- Z-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol
- 2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]ethanol
- 2-(4-(4-chloro-1
- 2-diphenyl-but-1-enyl)phenoxy)ethanol
- Ospemifene FC-1271a
- Ethanol,2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-
- CS-1039
- Ospemifene >
- 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol USP/EP/BP
- Ospemifene D4Q: What is
Ospemifene D4 Q: What is the CAS Number of
Ospemifene D4 Q: What is the storage condition of
Ospemifene D4 Q: What are the applications of
Ospemifene D4
- Ospemifene
- The department of pp meters
- 128607-22-7
- Inhibitors
