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Etalocib

Etalocib, 161172-51-6, 結(jié)構(gòu)式
Etalocib
CAS號:
161172-51-6
英文名:
Etalocib
英文別名:
VML 295;LY293111;Etalocib;Etalocib(LY293111);LY293111 Exclusive;YFIZRWPXUYFCSN-UHFFFAOYSA-N;2-(3-(3-((5-Ethyl-4'-fluoro-2-hydroxy-[1,1'-biphenyl]-4-yl)oxy)propoxy)-2-propylphenoxy)benzoic acid;2-(3-(3-((5-Ethyl-4'-fluoro-2-hydroxy-[1,1'-biphenyl]-4-yl)oxy)propoxy)-2-propylphenoxy)benzoic acid;Benzoic acid, 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]-;antiinflammatory,LY 293111,VML-295,VML 295,inhibit,LY-293111,Etalocib,Pulmonary,Leukotriene Receptor,Apoptosis,Inhibitor,asthma,bronchiectasis
中文名:
Etalocib
中文別名:
化合物ETALOCIB;LY293111,白三烯 (LTB4) 受體的拮抗劑;2-[2-丙基-3-[3-[2-乙基-4-(4-氟苯基)-5-羥基苯氧基]丙氧基]苯氧基]苯甲酸;2-(3-(3-((5-乙基-4'-氟-2-羥基-[1,1'-聯(lián)苯]-4-基)氧基)丙氧基)-2-丙基苯氧基)苯甲酸;2-(3-(3-((5-乙基-4'-氟-2-羥基-[1,1'-聯(lián)苯]-4-基)氧基)丙氧基)-2-丙基苯氧基)苯甲酸
CBNumber:
CB61856046
分子式:
C33H33FO6
分子量:
544.61
MOL File:
161172-51-6.mol

Etalocib化學(xué)性質(zhì)

熔點:
68-70 °C(Solv: acetonitrile (75-05-8))
沸點:
656.8±55.0 °C(Predicted)
密度:
1?+-.0.06 g/cm3(Predicted)
儲存條件:
Store at -20°C
溶解度:
DMSO:98.5(Max Conc. mg/mL);173.85(Max Conc. mM)
形態(tài):
Solid
酸度系數(shù)(pKa):
3.32±0.36(Predicted)
顏色:
White to off-white
安全信息

Etalocib性質(zhì)、用途與生產(chǎn)工藝

生物活性

Etalocib (LY293111) 是具有口服活性的白三烯 (LTB4) 受體的拮抗劑，抑制 [3H]LTB4 結(jié)合的Ki 值為 25 nM. Etalocib (LY293111) 抑制LTB4 誘導(dǎo)的鈣動員的 lC50 值為 20 nM。Etalocib (LY293111) 可誘導(dǎo)凋亡。

體外研究

Etalocib (LY293111) elicits a concentration-dependent inhibition of LTB 4 induced CD11b up-regulation.
Etalocib (LY293111) is an extremely potent and selective antagonist of human neutrophil function in vitro.
Etalocib (LY293111, 250 and 500 nM, 24-72 h) induces apoptosis and inhibits proliferation in human pancreatic cancer cells.

Cell Proliferation Assay

Cell Line: MiaPaCa-2 and AsPC-1 human pancreatic cancer cells. [3]
Concentration: 500 nM.
Incubation Time: 24, 48, and 72 h.
Result: Caused both a concentration-dependent and time-dependent inhibition of thymidine incorporation in both MiaPaCa-2 and AsPC-1 human pancreatic cancer cells.

Apoptosis Analysis

Cell Line: MiaPaCa-2 and AsPC-1 human pancreatic cancer cells.
Concentration: 250 and 500 nM.
Incubation Time: 24 h.
Result: Induced apoptosis in human pancreatic cancer cells.

體內(nèi)研究

Etalocib (LY293111) produces a dose-related inhibition of acute leukotriene B 4 -induced airway obstruction when administered i.v. (ED 50 =14 μg/kg) or p.o. (ED 50 =0.4 mg/kg).
Etalocib (LY293111, 10 mg/kg) inhibits A23187-induced lung inflammatory changes at 1 h.
Etalocib (LY293111, 250 mg/kg/day, orally) inhibits growth of human pancreatic cancer xenografts in athymic mice.

Animal Model: Guinea pigs.
Dosage: 1-10 mg/kg.
Administration: Orally once.
Result: A single 1 mg/kg oral dose inhibited excised lung gas volume increases by 76.7±7.1% (n=4, P<0.002) when given 8 h prior to leukotriene B 4 challenge, and 28.6±20.3% (n=4, NS) when given 24 h before challenge.
Had no effect (10 mg/kg) on pulmonary gas trapping at 1 h or 2 h after A23187 challenge. However, at 4 h, the pulmonary gas trapping response was significantly less than that of vehicle-treated controls and not different from sham values. The 10 mg/kg dose inhibited A23187-induced lung inflammatory changes at 1 h, but was without effect at 2 h or 4 h after challenge.

Etalocib 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

Etalocib 試劑級價格

更新日期產(chǎn)品編號產(chǎn)品名稱CAS編號包裝價格
2024/11/08HY-13628Etalocib1 mg1500元
2024/11/08HY-13628Etalocib
Etalocib		161172-51-65mg3300元

Etalocib 生產(chǎn)廠家

全球有 39家供應(yīng)商   Etalocib國內(nèi)生產(chǎn)廠家
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上海波以爾化工有限公司 021-50182298 021-50180596 sales@boylechem.com 中國 2208 55
上海超嵐化工科技中心 QQ:65489617 15618227136 Sales@ATKchemical.com 中國 7257 58
北京普西唐生物科技有限公司 010-60605840 18892239720 psaitong@jm-bio.com 中國 12306 58
上海宏葉生物科技有限公司 400-9205774 sales@glpbio.cn 中國 6777 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美國 32112 58
Career Henan Chemica Co +86-0371-86658258 +8613203830695 laboratory@coreychem.com 中國 30242 58
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ChemeGen 中國 18818260767 sales@chemegen.com 中國 11217 58
上海珞琺生化科技有限公司 021-51111890 15317326293 sales@molnova.com 中國 4195 58
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上海畢得醫(yī)藥科技股份有限公司 400-1647117 13681763483 product02@bidepharm.com 中國 62163 58
TargetMol中國（陶術(shù)生物） 4008200310 marketing@tsbiochem.com 中國 24647 58
河南阿爾法化工有限公司 0371-55013243 15324716602 2853979810@qq.com 中國 10039 58
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上海捷世凱生物科技有限公司 021-57520305 15221441005 lihua@jskchem.com 中國 49234 58
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南京世洲生物科技有限公司 025-85560043 15850508050 cindy.huang@synzest.com 中國 12005 58
上海阿拉丁生化科技股份有限公司 +86-18521732826 market@aladdin-e.com 中國 48461 58
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 ivan@atkchemical.com 中國 32951 60
Aladdin Scientific +1-+1(833)-552-7181 sales@aladdinsci.com 美國 57505 58
 

161172-51-6, Etalocib 相關(guān)搜索:

  • 抑制劑
  • 合成有機化合物配體
  • C33H33FO6
  • 2-(3-(3-((5-乙基-4'-氟-2-羥基-[1,1'-聯(lián)苯]-4-基)氧基)丙氧基)-2-丙基苯氧基)苯甲酸
  • 2-[2-丙基-3-[3-[2-乙基-4-(4-氟苯基)-5-羥基苯氧基]丙氧基]苯氧基]苯甲酸
  • LY293111,白三烯 (LTB4) 受體的拮抗劑
  • 化合物ETALOCIB
  • 2-(3-(3-((5-乙基-4'-氟-2-羥基-[1,1'-聯(lián)苯]-4-基)氧基)丙氧基)-2-丙基苯氧基)苯甲酸
  • 161172-51-6
  • 2-(3-(3-((5-Ethyl-4'-fluoro-2-hydroxy-[1,1'-biphenyl]-4-yl)oxy)propoxy)-2-propylphenoxy)benzoic acid
  • antiinflammatory,LY 293111,VML-295,VML 295,inhibit,LY-293111,Etalocib,Pulmonary,Leukotriene Receptor,Apoptosis,Inhibitor,asthma,bronchiectasis
  • Etalocib(LY293111)
  • YFIZRWPXUYFCSN-UHFFFAOYSA-N
  • LY293111 Exclusive
  • Benzoic acid, 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]-
  • 2-(3-(3-((5-Ethyl-4'-fluoro-2-hydroxy-[1,1'-biphenyl]-4-yl)oxy)propoxy)-2-propylphenoxy)benzoic acid
  • VML 295
  • LY293111
  • Etalocib
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