ML-180
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- CAS號(hào):
- 863588-32-3
- 英文名:
- ML-180
- 英文別名:
- SR1848;ML-180;ML-180 (SR1848);SR1848 >=98% (HPLC);ML-180, 10 mM in DMSO;6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2，4-dione;6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione;6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine- ,4(1H,3H)dione;6-(4-(3-chlorophenyl)piperazin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione;6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione
- 中文名:
- ML-180
- 中文別名:
- 化合物ML-180;化合物ML-180,10 MM DMSO 溶液;6-(4-(3-氯苯基)哌嗪-1-基)-3-環(huán)己基嘧啶-2,4(1H,3H)-二酮
- CBNumber:
- CB53152684
- 分子式:
- C20H25ClN4O2
- 分子量:
- 388.89
- MOL File:
- 863588-32-3.mol
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ML-180化學(xué)性質(zhì)
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密度:
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1.312±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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2-8°C
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溶解度:
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DMSO: 10 mg/ml
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形態(tài):
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A crystalline solid
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酸度系數(shù)(pKa):
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9.37±0.40(Predicted)
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顏色:
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Off-white to light yellow
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ML-180性質(zhì)、用途與生產(chǎn)工藝
ML-180 (SR1848) 是一種有效的 orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) 的反向激動(dòng)劑，其IC50值為3.7 μM。ML-180 具有依賴LRH-1的治療癌癥的潛力。
| Target | Value |
LRH1
(Cell-free assay)
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3.7 μM
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ML-180
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | HY-115613 | ML-180 | | 1 mg | 363元 |
| 2024/11/08 | HY-115613 | ML-180
ML-180 | 863588-32-3 | 5mg | 800元 |
863588-32-3, ML-180 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- 化合物ML-180,10 MM DMSO 溶液
- 化合物ML-180
- 6-(4-(3-氯苯基)哌嗪-1-基)-3-環(huán)己基嘧啶-2,4(1H,3H)-二酮
- 863588-32-3
- ML-180, 10 mM in DMSO
- 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione
- 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2，4-dione
- ML-180,steroidogenic,SR-1848,Inhibitor,ML180,Orphan,factor-1,LRH-1,cancers,nuclear,NR5A2,NR5A1,ML 180,inhibit,homolog,liver,SR 1848,receptor,SF-1
- 6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
- 6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine- ,4(1H,3H)dione
- ML-180 (SR1848)
- SR1848 >=98% (HPLC)
- 6-(4-(3-chlorophenyl)piperazin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione
- 2,4(1H,3H)-Pyrimidinedione, 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-
- 6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione
- SR1848
- ML-180