1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
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- CAS號:
- 1443246-62-5
- 英文名:
- VU0456810
- 英文別名:
- ML297;VU0456810;CID 56642816;ML297 (VU0456810);ML297 >=98% (HPLC);ML297, Pubchem: CID 56642816;ML 297 (Synonyms: VU 0456810;ML 297;ML-297;ML297;VU0456810;VU-0456810;VU 0456810;GIRK Activator, ML297 - CAS 1443246-62-5 - Calbiochem;1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
- 中文名:
- 1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
- 中文別名:
- 化合物ML297;ML 297,KIR3.1 / 3.2(GIRK1 / 2)通道激活劑;1-(3,4-二氟苯基)-3-(3-甲基-1-苯基-1H-吡唑-5-基)脲
- CBNumber:
- CB22750693
- 分子式:
- C17H14F2N4O
- 分子量:
- 328.32
- MOL File:
- 1443246-62-5.mol
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1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA化學(xué)性質(zhì)
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沸點:
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377.8±42.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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儲存條件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO: soluble15mg/mL, clear
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酸度系數(shù)(pKa):
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12.54±0.70(Predicted)
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形態(tài):
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White powder
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顏色:
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white to beige
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穩(wěn)定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA性質(zhì)、用途與生產(chǎn)工藝
ML-297 (VU 0456810, CID 56642816)是一種有效的、選擇性的 Kir3.1/3.2 (G protein-coupled inwardly rectifying potassium, GIRK1/2) 通道的激活劑，其對于GIRK1/2和GIRK1/4的EC50值分別為0.16 μM和1.8 μM。ML-297 具有治療癲癇的潛力。
| Target | Value |
GIRK1/2
(Cell-free assay)
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0.16 μM
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GIRK1/4
(Cell-free assay)
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1.8 μM
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ML 297 is completely inactive for GIRK
2/3
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ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC
50
of 162 nM.
ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK
2
alone and GIRKGIRK
2/3
.
ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment.
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Animal Model:
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8-10 months old C57/BL6 male mice (approximately 30 g)
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Dosage:
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60 mg/kg
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Administration:
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Intraperitoneal injection
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Result:
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Most of the animals neither convulsions nor death.
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1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2024/11/08 | HY-110192 | 1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
ML 297 | 1443246-62-5 | 5mg | 700元 |
| 2024/11/08 | HY-110192 | 1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
ML 297 | 1443246-62-5 | 10mM * 1mLin DMSO | 770元 |
1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
生產(chǎn)廠家
1443246-62-5, 1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA 相關(guān)搜索:
- 抑制劑
- 合成有機化合物配體
- ML 297,KIR3.1 / 3.2(GIRK1 / 2)通道激活劑
- 1-(3,4-二氟苯基)-3-(3-甲基-1-苯基-1H-吡唑-5-基)脲
- 化合物ML297
- 1443246-62-5
- CID 56642816,epilepsy,GIRK1/2,Potassium Channel,CID56642816,VU0456810,CID-56642816,GIRK,ML-297,convulsions,inhibit,KcsA,ML 297,VU-0456810,VU 0456810,Inhibitor
- ML297 >=98% (HPLC)
- Urea, N-(3,4-difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-
- ML 297 (Synonyms: VU 0456810
- GIRK Activator, ML297 - CAS 1443246-62-5 - Calbiochem
- ML 297;ML-297;ML297;VU0456810;VU-0456810;VU 0456810
- ML297 (VU0456810)
- ML297, Pubchem: CID 56642816
- 1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
- VU0456810
- ML297
- CID 56642816
- 1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea