烏本( 箭毒) 苷, 哇巴因
|
|
|
- CAS號(hào):
- 11018-89-6
- 英文名:
- OUABAIN OCTAHYDRATE
- 英文別名:
- Ouabain CRS;OUABAIN 8H2O;OUABAIN 8H20;G-Strophantin;STROPHANTHIN G;OUABAIN HYDRATE;OUBAIN OCTAHYDRATE;OUABAIN OCTAHYDRATE;(-)-OUABAIN OCTAHYDRATE;Ouabain octahydrate,96%
- 中文名:
- 烏本( 箭毒) 苷, 哇巴因
- 中文別名:
- 烏本苷;毒毛旋花苷;八水合烏本苷;十水合烏本苷;烏本苷八水合物;哇巴因八水合物;烏本苷/A1A;哇巴因 EP標(biāo)準(zhǔn)品;G毒毛旋花苷/烏本苷;烏本( 箭毒) 苷, 哇巴因
- CBNumber:
- CB4469924
- 分子式:
- C29H60O20
- 分子量:
- 728.77
- MOL File:
- 11018-89-6.mol
|
|
|
烏本( 箭毒) 苷, 哇巴因化學(xué)性質(zhì)
-
熔點(diǎn):
-
260 °C
-
|
-
儲(chǔ)存條件:
-
room temp
-
|
-
溶解度:
-
H2O: 10 mg/mL cold
-
|
-
形態(tài):
-
powder
-
|
-
顏色:
-
white
-
|
-
旋光性 (optical activity):
-
[α]25/D 31 to 32.5° in H2O(lit.)
-
|
-
水溶解性:
-
Soluble in water.
-
|
-
敏感性:
-
Light Sensitive
-
|
-
BRN:
-
101712
-
|
-
穩(wěn)定性:
-
Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
-
|
-
EPA化學(xué)物質(zhì)信息:
-
Card-20(22)-enolide, 3-[(6-deoxy-.alpha.-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, octahydrate, (1.beta.,3.beta.,5.beta.,11.alpha.)- (11018-89-6)
-
|
烏本( 箭毒) 苷, 哇巴因性質(zhì)、用途與生產(chǎn)工藝
Ouabain Octahydrate 是 Na+/K+-ATPase 抑制劑，有潛力用于充血性心力衰竭的研究。
Ouabain (100 μM) induces NLRP3 inflammasome activation and IL-1β release in macrophages. Ouabain-induced NLRP3 inflammasome activation is mediated through K
+
efflux. Ouabain (3 nM) alters the expression of EMT markers in NHK and ADPKD cells, and modifies cell-cell adhesion properties in ADPKD. Moreover, ouabain enhances migration of ADPKD cells, selectively modulates tight junctions, and modulates adherens junctions in ADPKD cells in a selective manner. Ouabain also activates TGFβ-Smad3 signaling, alters TER in ADPKD cells. Ouabain (25, 50 or 100 nM) treatment significantly reduces cell proliferation and viability in Raji cells in a dose-dependent manner, with IC
50
of 76.48±4.03 nM. Ouabain increases the number of apoptotic cells, induces autophagy, and upregulates Beclin-1 in Raji cells.
Ouabain (3 mg/kg) significantly decreases cardiac contractile force with an enlarged LVESD when mice are primed with LPS. IL-1β deficiency attenuates ouabain-induced cardiac dysfunction and injury. IL-1β secreted by infiltrated macrophages contributes to ouabain-induced cardiac inflammation. Deficiency of NLRP3 and Casp1 attenuates ouabain-induced cardiac dysfunction and macrophage infiltration. Ouabain (30 μg/kg, i.p.) modulates ABCB1 activity in thymocytes of Wistar rats and it has the same effect on Swiss mice at 300 μg/kg. After 14 days of ouabain treatment, the MAP of rats is significantly elevated.
用途
Na+, K+-ATPase的典型抑制劑,抑制陽(yáng)離子輸送.Cardiac glycoside.生化研究
類(lèi)別
有毒物質(zhì)
毒性分級(jí)
劇毒
急性毒性
腹腔-小鼠 LD50： 1.213 毫克/公斤; 靜脈-小鼠 LD50: 3.750 毫克/公斤
可燃性危險(xiǎn)特性
可燃, 火場(chǎng)排出辛辣刺激煙霧
儲(chǔ)運(yùn)特性
庫(kù)房低溫, 通風(fēng), 干燥; 與食品原料分開(kāi)存放
滅火劑
水, 二氧化碳, 干粉, 砂土
烏本( 箭毒) 苷, 哇巴因
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | 16173 | 八水合烏本苷
Ouabain octahydrate, 96% | 11018-89-6 | 250mg | 960元 |
| 2024/11/08 | 16173 | 八水合烏本苷
Ouabain octahydrate, 96% | 11018-89-6 | 1g | 2018元 |
烏本( 箭毒) 苷, 哇巴因
生產(chǎn)廠(chǎng)家
11018-89-6, 烏本( 箭毒) 苷, 哇巴因 相關(guān)搜索:
- Steroids
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- Heterocycles
- Carbohydrates & Derivatives
- 細(xì)胞生物學(xué)試劑
- 細(xì)胞信號(hào)和神經(jīng)生物學(xué)
- 小分子抑制劑，天然產(chǎn)物
- 小分子抑制劑
- 生物活性小分子
- 細(xì)胞生物學(xué)
- Cell Biology
- Biochemicals and Reagents
- BioChemical
- Cell Signaling and Neuroscience
- Conjugates
- Voltage-gated Ion Channels
- Sterols
- Sodium Channel Modulators
- Monovalent Ion Channels
- Other Sodium Channel Modulators
- Lipids
- Ion Channels
- C28H44O12x8H2O
- C29H44O128H2O
- 烏本苷/A1A
- G-羊角拗質(zhì)八水化合物,毒毛旋花苷G
- 哇巴因八水合物
- 八水合烏本苷
- 哇巴因 EP標(biāo)準(zhǔn)品
- NA+/K+-ATPASE抑制劑(OUABAIN OCTAHYDRATE)
- G毒毛旋花苷/烏本苷
- 烏本苷
- 十水合烏本苷
- 烏本( 箭毒) 苷, 哇巴因
- 毒毛旋花苷
- 烏本苷八水合物
- 毒毛旋花苷G (羊角拗質(zhì)、烏本( 箭毒) 苷、哇巴因、烏本苷、G毒毛旋花苷、烏本苷八水合物)
- 11018-89-6
- g-Strophanthin Octahydrate, ≥ 98.0%
- Na+/K+ ATPase,Ouabain,Sodium potassium pump,inhibit,Inhibitor,Autophagy,Ouabain octahydrate
- (1β,3β,5β,11α)-3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-Card-20(22)-enolide hydrate (1:8)
- Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, hydrate (1:8), (1β,3β,5β,11α)-
- Ouabain Octahydrate (Acocantherine)
- Ouabain CRS
- Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem
- 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside)
Acocantherine
G-Strophanthin
G-Strophantin octahydrate
- Strophanthin glycosides G
- Ouabain octahydrate 96%
- Card-20(22)-enolide,3-[(6-deoxy-a-L-Mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-,hydrate (1:8), (1b,3b,5b,11a)-
- (1beta,3beta,5beta,11alpha)-3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-card-20(22)-enolide octahydrate
- G-STROPHANTIN OCTAHYDRATE
- G-STROPHANTHIN OCTAHYDRATE
- (1β,3β,5β,11α)-3-[(6-Deoxy-α-L-Mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide Octahydrate
- G-Strophantin
- Ouabain octahydrate, 96% 1GR
- Acocantherine, G-Strophanthin, 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside)