95975-55-6
95975-55-6 結(jié)構(gòu)式
基本信息
咕咕草
香膠甾酮
CIS-4,17(20)-PREGNADIENE-3,16-DIONE
CIS GUGGULSTERONE
GUGGULESTERONE Z
GUGGULSTERONE
GUGGULSTERONE Z
GUGGULSTERONE (Z FORM)
GUGULSTERONE
PREGNA-4,17(20)-DIENE-3,16-DIONE
(Z)-GUGGULSTERONE
(8S,9R,10R,13S,14S,17E)-17-(1-methoxyethylidene)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
pregna-4,17-diene-3,16-dione
GUGGULISTERONES 95%
(17Z)-Pregna-4,17(20)-diene-3,16-dione
(Z)-Guggulsterone
物理化學(xué)性質(zhì)
常見問題列表
香膠甾酮是一種植物甾醇，來自 Commiphora wightii 樹的樹膠脂。 香膠甾酮通過下調(diào)抗細(xì)胞凋亡 (apoptosis) 基因產(chǎn)物 (IAP1，xIAP，Bfl-1/A1，Bcl-2，cFLIP，survivin)，調(diào)節(jié)細(xì)胞周期蛋白 (cyclin D1，c-Myc)，激活 caspases，JNK，抑制 Akt，抑制多種腫瘤細(xì)胞的生長并誘導(dǎo)細(xì)胞凋亡。香膠甾酮通過調(diào)節(jié)幾種轉(zhuǎn)錄因子介導(dǎo)基因表達(dá)，包括 NF-κB，STAT3，C /EBPα，雄激素受體 (androgen receptor) 和糖皮質(zhì)激素受體(glucocorticoid receptors)。它是一種法尼醇 X 受體 (FXR) 拮抗劑，可降低 CDCA 誘導(dǎo)的 FXR 活化，Z- 和 E-Guggulsterone 的 IC50 分別為 17 和 15 μM。
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JNK
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Akt
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Caspase
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Guggulsterone (0.5-20 μM; 24 hours) suppresses TREM-1, TLR4 and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS.
Western Blot Analysis
| Cell Line: | RAW 264.7 murine macrophage cells |
| Concentration: | 0.5, 5, 10, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Suppressed TREM-1, TLR4, and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS. |
Guggulsterone (orally; 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis.
| Animal Model: | Wild-type mice with TNBS-induced colitis |
| Dosage: | 100 mg/kg |
| Administration: | Orally; once per day; for 8 days |
| Result: | Improved the survival rates of wild-type mice with TNBS-induced colitis. |