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90-18-6

中文名稱 六羥黃酮/櫟草亭
英文名稱 3,3',4',5,6,7-HEXAHYDROXYFLAVONE
CAS 90-18-6
分子式 C15H10O8
分子量 318.24
MOL 文件 90-18-6.mol
更新日期 2024/10/25 15:17:16
90-18-6 結構式 90-18-6 結構式

基本信息

中文別名
櫟草亭
六羥黃酮/櫟草亭
槲皮萬壽菊素櫟草亭
櫟草亭,槲皮萬壽菊素
3,3',4',5,6,7-六羥基黃酮
英文別名
QUERCETAGIN
QUERCETAGETIN
QUERCETAGENIN
6-Hydroxyquercetin
6,7,4'-Quercetagetin
QUEBRACHITOL, (-)-(RG)
Quercetagetin 7-glucoside
3,5,6,7,3',4'-HEXAHYDROXYFLAVONE
3,3',4',5,6,7-HEXAHYDROXYFLAVONE
QuercetagitrinQuercetagetin 7-glucoside
所屬類別
生物化工:提取物

物理化學性質

外觀性狀來源于萬壽菊
熔點>300°C
沸點732.4±60.0 °C(Predicted)
密度1.912±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 125 mg/mL (392.79 mM; Need ultrasonic)
酸度系數(shù)(pKa)6.12±0.40(Predicted)
形態(tài)結晶固體
顏色Light yellow to yellow
LogP2.230 (est)

常見問題列表

生物活性
Quercetagetin (6-Hydroxyquercetin) 是從 Citrus unshiu (C. unshiu) 果皮中分離的主要類黃酮。Quercetagetin 是一種中等強度和選擇性的,細胞滲透性的 pim-1 激酶抑制,IC50 為 0.34 μM。具有抗炎和抗腫瘤活性。
靶點

PIM1

0.34 μM (IC 50 )

PIM2

3.45 μM (IC 50 )

RSK2

2.82 μM (IC 50 )

PKA

21.2 μM (IC 50 )

體外研究

Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC 50 s of 3.45, 21.2, and 2.82 μM, respectively.
Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED 50 is 3.8 μM.

Cell Viability Assay

Cell Line: RWPE2 prostate cancer cells
Concentration: 0.1, 1, 10, and 100 μM
Incubation Time: 72 hours
Result: Inhibited growth of RWPE2 prostate cancer cells with average ED 50 is 3.8 μM.
體內(nèi)研究

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively.

Animal Model: SKH-1 hairless mice model
Dosage: 4 or 20 nmol
Administration: Topical application; 28 weeks
Result: Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.
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