84692-91-1
中文名稱(chēng)
小白菊內(nèi)酯衍生物
英文名稱(chēng)
arglabin
CAS
84692-91-1
分子式
C15H18O3
分子量
246.3
MOL 文件
84692-91-1.mol
更新日期
2024/10/23 10:49:12
84692-91-1 結(jié)構(gòu)式
基本信息
中文別名
阿格拉賓阿格拉賓, BR
小白菊內(nèi)酯衍生物
英文別名
CS-1320arglabin
Arglabine
Arglabin, BR
(+)-Arglabin
Arglabin 84692-91-1
Arglabin ((+)-Arglabin)
(3aS)-2,3,3aβ,4,5β,6,6a,7,9aβ,9bα-Decahydro-6α,6aα-epoxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2-one
(3aR,4aS)-1,4aα-Dimethyl-7-methylene-4a,5,6,6aα,9aβ,9bα-hexahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(7H)-one
(3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one
所屬類(lèi)別
生物化工：植物提取物物理化學(xué)性質(zhì)
熔點(diǎn)100-102 °C
沸點(diǎn)404.6±45.0 °C(Predicted)
密度1.22±0.1 g/cm3(Predicted)
儲(chǔ)存條件Amber Vial, -20°C Freezer, Under inert atmosphere
溶解度可溶于氯仿（少許）
形態(tài)固體
顏色米白色
常見(jiàn)問(wèn)題列表
生物活性
Arglabin ((+)-Arglabin)，從青蒿中分離出的天然產(chǎn)物，是一種 NLRP3 炎癥小體 (NLRP3 inflammasome) 抑制劑。Arglabin 具有抗炎和抗腫瘤活性。Arglabin 的抗腫瘤活性是通過(guò)抑制 farnesyl 轉(zhuǎn)移酶而激活 RAS 原癌基因來(lái)實(shí)現(xiàn)的。體外研究
The antitumor activity of arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene, a process that is believed to play a pivotal role in 20-30% of all human tumors. It actually inhibits the incorporation of farnesyl pyrophosphate into human H-ras proteins by the enzyme farnesyl transferase (FTase).
體內(nèi)研究
Arglabin reduces inflammation and plasma lipids, increases autophagy, and orients tissue macrophages into an anti-inflammatory phenotype in ApoE2.Ki mice fed a high-fat diet.