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845959-50-4

中文名稱 米托蒽醌甲磺酸鹽
英文名稱 Mitoquinone mesylate
CAS 845959-50-4
分子式 C38H47O7PS
分子量 678.814
MOL 文件 845959-50-4.mol
更新日期 2024/10/30 11:29:01
845959-50-4 結(jié)構(gòu)式 845959-50-4 結(jié)構(gòu)式

基本信息

中文別名
米托蒽醌甲磺酸鹽
英文別名
MitoQ
MitoQ mesylate
MitoQ10 mesylate
Mitoquinol Mesylate
Mitoquinone mesylate
Mitoquinone mesylate, ethanol solution
Mitoquinone mesylate (Mitoquinone methanesulfonate
10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium,methanesulfonate

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C
溶解度溶于二甲基亞砜。
形態(tài)蠟狀固體
顏色橙色
穩(wěn)定性可在-20°C下的DMSO中的溶液儲(chǔ)存長(zhǎng)達(dá)3個(gè)月。
米托蒽醌甲磺酸鹽價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19HY-100116A米托蒽醌甲磺酸鹽
Mitoquinone mesylate
845959-50-45mg1100元
2024/08/19HY-100116A米托蒽醌甲磺酸鹽
Mitoquinone mesylate
845959-50-410mM * 1mLin DMSO1643元
2024/08/19S8978米托蒽醌甲磺酸鹽
Mitoquinone mesylate
845959-50-45mg1284.56元

常見問題列表

生物活性
Mitoquinone mesylate (MitoQ mesylate, MitoQ10, Mitoubiquinone) 是一種基于TPP的線粒體mitochondria靶向抗氧化劑,可阻斷H2O2誘導(dǎo)的細(xì)胞內(nèi) ROS 反應(yīng)并防止氧化損傷。
靶點(diǎn)
TargetValue
mitochondria
()
ROS
()
體外研究

Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant.The optimal doses for Mitoquinone (MitoQ) and DecylTPP treatment are selected from dose-response experiments during 4-h cold storage (CS). The potential protective benefits of Mitoquinone treatment against CS injury are tested initially using MitoSOX Red, a mitochondrial-targeted fluorescent dye that measures mitochondrial superoxide generation. Normal rat kidney (NRK) cells exposed to CS result in a ~2-fold increase in fluorescence due to mitochondrial superoxide compared with untreated cells. Mitoquinone offers significant protection against CS-induced mitochondrial superoxide generation; whereas the control compound DecylTPP does not offer any protection. Mitoquinone treatment markedly decreases mitochondrial superoxide generation, whereas kidneys treated with DecylTPP have comparable levels of mitochondrial superoxide to kidneys exposed to CS alone.

體內(nèi)研究

Mitoquinone (MitoQ) treatment significantly reduces pancreatic oedema and neutrophil infiltration. MitoQ dose-dependently increases serum amylase with an approximate doubling at the higher dose. MitoQ treatment nearly doubles lung MPO activity induced by Caerulein with a significant increase of serum IL-6 levels also evident at 10?mg/kg (dose 1).

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