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8048-52-0

中文名稱 吖啶黃
英文名稱 ACRIFLAVINE
CAS 8048-52-0
分子式 C27H25ClN6
MDL 編號 MFCD00064307
分子量 468.98
MOL 文件 8048-52-0.mol
更新日期 2024/12/16 10:51:48
8048-52-0 結(jié)構(gòu)式 8048-52-0 結(jié)構(gòu)式

基本信息

中文別名
吖啶黃素
吖啶黃
吖黃素
吖啶黃素
英文別名
2,8-DIAMINO-10-METHYLACRIDINIUM CHLORIDE
3,6-DIAMINO-10-METHYLACRIDINIUM CHLORIDE
ACRIFLAVINE
ACRIFLAVINE BASE
ACRIFLAVINE NEUTRAL
CI 46000
CI NO 46000
EUFLAVIN
EUFLAVINE
TRYPAFLAVINE
TRYPAFLAVINE FS
XANTHACRIDINE
2,8-diamino-10-methylacridiniumchloridemixturewith2,8-diaminoacridine
3,6-diamino-10-methylacridiniumchloridemixturewith3,6-acridinediamine
3,6-diaminoacridinemixturewith3,6-diamino-10-methylacridiniumchloride
acridinium,3,6-diamino-10-methyl-,chloridemixedwith3,6-acridinediamine
angiflan
assiflavine
bialflavina
bioacridin
所屬類別
原料藥:消毒防腐藥

物理化學(xué)性質(zhì)

熔點179-181 °C
沸點612.69°C (rough estimate)
密度1.0933 (rough estimate)
折射率1.6000 (estimate)
儲存條件-20°C儲存
溶解度在水中的溶解度為0.33g/mL(lit.)(lit.)
形態(tài)粉末
顏色深橙色至棕紅色
Merck123
CAS 數(shù)據(jù)庫8048-52-0(CAS DataBase Reference)
EPA化學(xué)物質(zhì)信息Xanthacridinum (8048-52-0)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
危險品標(biāo)志Xn,N
危險類別碼R22-R37/38-R41-R50/53
安全說明S26-S39-S60-S61
危險品運輸編號UN 3077 9/PG 3
WGK Germany3
RTECS號AR9660000
海關(guān)編碼29339900

應(yīng)用領(lǐng)域

用途一
添加于李氏菌增菌肉湯基礎(chǔ)中。
吖啶黃價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/11XW80485202吖啶黃素
acriflavine;3,6-diamino-10-methylacridinium chloride mixture with 3,6-diaminoacridine(proflavine);euflavine
8048-52-025G483元
2024/11/11XW80485201吖啶黃素
acriflavine;3,6-diamino-10-methylacridinium chloride mixture with 3,6-diaminoacridine(proflavine);euflavine
8048-52-05G114元
2024/11/0821140吖啶黃
Acriflavine neutral, 13.3-15.8% chlorine, Thermo Scientific Chemicals
8048-52-025g726元

常見問題列表

生物活性
Acriflavine是用于標(biāo)記高分子量RNA的熒光染料。它也是一種局部防腐劑。
體外研究

Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells.

體內(nèi)研究

Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis.

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