78416-81-6
中文名稱
鹽酸曲林菌素
英文名稱
HL 725
CAS
78416-81-6
分子式
C24H28ClN3O3
分子量
441.95
MOL 文件
78416-81-6.mol
更新日期
2023/03/20 15:41:25
78416-81-6 結構式
基本信息
中文別名
曲喹辛鹽酸曲林菌素
英文別名
HL 725HL 725 HCL
TREQUINSIN
Trequinsin, HCl
TREQUINSIN HYDROCHLORIDE
DTCZZBVPTHVXFA-OSMRDGEFSA-N
TREQUINSIN HYDROCHLORIDE MINIMUM 98%
4,6-trimethylphenyl)imino)--2-((monohydrochloride
Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem
4h-pyrimido(6,1-a)isoquinolin-4-one,2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl
物理化學性質
熔點210-211 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
儲存條件Desiccate at RT
溶解度DMSO: 100 mM; Ethanol: 100 mM
形態(tài)淡黃色固體
顏色Light yellow to yellow
常見問題列表
生物活性
Trequinsin hydrochloride (HL 725) 是高效的血小板 CAMP 磷酸二酯酶 (PDE)的抑制劑，IC50的0.25 nM。Trequinsin hydrochloride (HL 725) 是 ADP、膠原蛋白、凝血酶和腎上腺素在體外誘導的血小板聚集的極有效抑制劑。體外研究
Trequinsin hydrochloride exerts besides its cardiovascular and antihypertensive qualities very potent antiplatelet activities.
Trequinsin hydrochloride is an efficacious agonist of [Ca
2+
]
i
.
Cell Viability Assay
| Cell Line: | Samples from healthy volunteer research donors with normal sperm motility parameters in agreement with World Health Organization 2010 criteria. |
| Concentration: | 10 μM. |
| Incubation Time: | 20 min. |
| Result: | Caused a concentrationdependent increase in [Ca 2+ ] i (EC 50 = 6.4 μM [95% confidence interval (CI): 4.1-9.9 μM]). |