77-59-8
基本信息
番茄堿標(biāo)準(zhǔn)品
番茄堿?, >98%
番茄堿, 來源于番茄
omatidine
TOMATADINE
TOMATIDINE
NSC 226903
TOMATIDINE(RG)
Spirosolan-3-ol
Tomatidine, >98%
5alpha-Tomatidan-3beta-ol
Spirosolan-3-ol,(3β,5α,22β,25S)-
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-N2149 | 番茄堿 Tomatidine | 77-59-8 | 5 mg | 500元 |
2024/11/08 | HY-N2149 | 番茄堿 Tomatidine | 77-59-8 | 10 mg | 700元 |
2024/11/08 | HY-N2149 | 番茄堿 Tomatidine | 77-59-8 | 25mg | 1400元 |
常見問題列表
p65
|
JNK
|
Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.