748810-28-8
基本信息
鹽酸維那卡蘭
Vernakalant HCl
RSD1235 hydrochloride
RSD 1235 hydrochloride
RSD-1235 hydrochloride
VERNAKALANT HYDROCHLORIDE
Vernakalant hydrochloride (usan)
Vernakalant ((3R,1'R,2'R)-Isomer) HCl
RSD1235 HYDROCHLORIDE
RSD 1235 HYDROCHLORIDE
RSD-1235 HYDROCHLORIDE
(R)-1-((1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexyl)pyrrolidin-3-ol hydrochloride
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-14183 | 鹽酸維那卡蘭 Vernakalant Hydrochloride | 748810-28-8 | 2mg | 950元 |
2024/11/08 | HY-14183 | 鹽酸維那卡蘭 Vernakalant Hydrochloride | 748810-28-8 | 5mg | 1800元 |
2024/11/08 | HY-14183 | 鹽酸維那卡蘭 Vernakalant Hydrochloride | 748810-28-8 | 10mM * 1mLin DMSO | 1980元 |
常見(jiàn)問(wèn)題列表
IC50: 13.35±0.93 μM (Kv1.5 channel wt ), 0.61±0.03 μM ( I508F ), 1.63±0.09 μM (Kv1.5 channel T479A )
Block of Kv1.5 by Vernakalant Hydrochloride is mediated after channel activation, because Vernakalant causes a relatively rapid onset of block of channel current upon depolarization but little evidence of resting or “tonic” block of the channel. In the presence of 10 μM Vernakalant, rapid block is apparent after channel opening, and a steady-state current level is rapidly reached. The most important effect is the reduction in potency for Vernakalant centered at I502A, which had an IC 50 of 329±19 μM (n=4-10), compared with a control IC 50 of 13.4±0.9 μM (n=5-23), which is a 25-fold decrease in potency. V505A, I508A, T480A, and C500A showed lesser reductions in potency on Kv1.5, of between 3- and 4-fold. I508Y in our experiments increased the IC 50 for Vernakalant on Kv1.5 to 24.7 μM, again similar to the reported value for hERG.