68399-76-8
中文名稱(chēng)
乳清酸鋅二水合物
英文名稱(chēng)
OROTIC ACID ZINC SALT DIHYDRATE
CAS
68399-76-8
分子式
C10H10N4O10Zn
分子量
411.6
MOL 文件
68399-76-8.mol
68399-76-8 結(jié)構(gòu)式
基本信息
中文別名
乳清酸鋅二水合物乳清酸 鋅鹽 二水合物
乳清酸鋅二水合物|乳清酸鋅
英文別名
ZINC OROTATEZincorotate2H2O
Orotic acid zinc
Orotic acid zinc saL
Zn Orotate USP/EP/BP
OROTIC ACID ZINC SALT DIHYDRATE
Orotic acid dihydrate zinc salt
Orotic acid zinc salt dihydrate >=98.0%
zinc 2,4-dioxo-1H-pyrimidine-6-carboxylate
zinc 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylate (1:2)
所屬類(lèi)別
食品添加劑常見(jiàn)問(wèn)題列表
生物活性
Orotic acid (zinc)，一種嘧啶核苷酸和 RNA 生物合成的前體，從線(xiàn)粒體二氫乳清酸脫氫酶 (DHODH) 中釋放，通過(guò)細(xì)胞質(zhì) UMP 合酶轉(zhuǎn)化為 UMP。Orotic acid (zinc) 是尿素循環(huán)異常的常規(guī)新生兒篩查中的測(cè)量指標(biāo)。Orotic acid (zinc) 可引起大鼠肝脂肪變性和肝腫大。體外研究
Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes.
體內(nèi)研究
Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD).
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3.