67483-13-0
中文名稱
4,4'-二異硫氰酸基-2,2'-二苯乙烯磺酸二鈉[蛋白質(zhì)改性試劑]
英文名稱
DIDS
CAS
67483-13-0
分子式
C16H8N2Na2O6S4
分子量
498.48
MOL 文件
67483-13-0.mol
更新日期
2023/03/20 15:41:19
67483-13-0 結(jié)構(gòu)式
基本信息
中文別名
DIDS4,4'-二異硫氰酰-2,2'-二磺酸二鈉鹽晶體
4,4'-二異硫氰酸基-2,2'-二苯乙烯磺酸二鈉
4,4'-二異硫氰酸基-2,2'-二苯乙烯磺酸二鈉[蛋白質(zhì)改性試劑]
英文別名
DIDSDIDS,90%
DIDS DISODIUM SALT
DIDS (sodium salt)
Hydrate [Protein Modification Reagent]
4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID, 2NA
DISODIUM 4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONATE
4,4'-diisothiocyanato-2,2'-stilbenedisulfonic acid sodium
4,4'-DIISOTHIOCYANOSTILBENE-2,2'-SUFONIC ACID SODIUM SALT
4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC A. NA2-SLT HY
所屬類別
生物化工：熒光成像物理化學(xué)性質(zhì)
熔點>300°C
密度1.54
儲存條件2-8°C
儲存條件2-8°C
溶解度0.1 M potassium bicarbonate: 50 mg/mL
溶解度0.1 M 碳酸氫鉀：50 mg/mL
形態(tài)powder
顏色yellow
穩(wěn)定性建議在-20°C下干燥儲存
CAS 數(shù)據(jù)庫67483-13-0
安全數(shù)據(jù)
警示詞警告
危險性描述H315-H319
危險品標志Xn
危險類別碼36/37/38-42-26-22
危險類別碼36/37/38-42-26-22
安全說明22-26-36/37/38
安全說明22-26-36/37/38
WGK Germany3
WGK Germany3
海關(guān)編碼29309090
常見問題列表
生物活性
DIDS sodium salt (MDL101114ZA) 是 ABCA1 和 VDAC1 的雙抑制劑。靶點
ABCA1, VDAC1.
體外研究
Concentration less than 400 μM DIDS has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. At the concentration of 400 μM DIDS itself slightly decreases the cell viability, although there is no significant statistic difference as compared with the untreated control. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation.