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65195-55-3

中文名稱 阿維菌素 B1a
英文名稱 Avermectin B1a
CAS 65195-55-3
分子式 C48H72O14
分子量 873.09
MOL 文件 65195-55-3.mol
更新日期 2025/01/20 19:39:08
65195-55-3 結(jié)構(gòu)式 65195-55-3 結(jié)構(gòu)式

基本信息

中文別名
阿巴汀
齊螨素
克螨靈
愛弗菌素
阿維菌素原料藥
伊維菌素雜質(zhì)3
依維菌素雜質(zhì)1
阿維菌素 B1a
伊維菌素EP雜質(zhì)A
英文別名
C-076B1a
Abamectina
ABERMECTINS
Abamectinum
Avamectin B1a
AbaMectin B1a
avermectin b1a
Antibiotic C-076B1a
Abamectine [french]
Abamectinum [latin]
所屬類別
化學(xué)農(nóng)藥原藥:殺螨劑

物理化學(xué)性質(zhì)

沸點(diǎn)940.9±65.0 °C(Predicted)
密度1.24±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度≥143.4 mg/mL in DMSO; ≥11.86 mg/mL in EtOH with ultrasonic; insoluble in H2O
酸度系數(shù)(pKa)12.42±0.70(Predicted)
形態(tài)粉末
顏色White to light yellow
穩(wěn)定性吸濕性
EPA化學(xué)物質(zhì)信息Avermectin A1a, 5-O-demethyl-(65195-55-3)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS08,GHS09,GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H330-H410-H300-H361d-H372
危險(xiǎn)品運(yùn)輸編號(hào)2588
危險(xiǎn)等級(jí)6.1(a)
包裝類別II
毒性LD20 orl-rat: 10 mg/kg JAFCAU 32,94,84

常見問題列表

用途
阿維菌素 B1a是一種大環(huán)內(nèi)酯二糖驅(qū)蟲劑,可與哺乳動(dòng)物 GABAA 受體上的高親和力和低親和力位點(diǎn)結(jié)合。與高親和力位點(diǎn)結(jié)合可激活受體以增加氯離子流入,而與低親和力位點(diǎn)結(jié)合則可阻斷通道。阿維菌素 B1a 可抑制甘氨酸受體拮抗劑士的寧與大鼠脊髓膜和可溶性受體的結(jié)合(Kis 分別為 1.3 和 3.6 μM)。含有阿維菌素 B1a(>80%)和阿維菌素 B1b(~20%,Cay-17453)的配方可用作殺蟲劑和獸醫(yī)驅(qū)蟲配方,如阿維菌素(Cay-19201)。
生物活性
Avermectin B1a 是一種抗寄生蟲劑,能夠使線蟲癱瘓。
體外研究

[ 3 H]AVM B1a preferentially binds to synaptic membranes from several regions of rat brain. [ 3 H]AVM B1a specific binding to intact monolayers of granule cells increases rapidly with time of incubation and reaches equilibrium after approximately 20 min at 24°C. Higher concentrations of [ 3 H]AVM B1a leads to markedly greater nonspecific binding, 60% at 25 nM. Various AVM analogs also produce concentration-dependent inhibition of [ 3 H]AVM B1a binding in intact cerebellar neurons. AVM B1a and moxidectin are similar in potency (IC 50 values, 120 and 126 nM, respectively). AVMB1a-stimulated chloride efflux from mouse brain synaptic vesicles results from the activation of GABA-insensitive chloride channels and that this action is distinct from their previously documented effects on GABA-gated chloride channels in mouse brain preparations.

體內(nèi)研究

Bacteria are significantly inhibited when the AVM B1a concentration is higher than 83.3 mg/kg, while fungi are less impaired in soil. Soil respiration is also inhibited by high concentration AVM B1a, which differs with soil types. The half lethal dosage (LD 50 ) of AVM B1a to soil earthworm is estimated as 4.63 mg × cm 2 in filter paper contact test, and as 24.13 and 17.06 mg/kg, respectively after treated 7 and 14 days in artificial soil. Iin artificial soil, the LC50 of AVM B1a on earthworms are 24.1 mg/kg and 17.1 mg/kg, respectively, for 7 and 14 days. About 80.0% and 94.8% of the accumulated AVM B1a are eliminated respectively in two groups within 1 day after they are exposed to AVM B1a-free soil, but a trace amount of AVM B1a is found for a relative long time in earthworms.

阿維菌素 B1a價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-15308阿維菌素 B1a
Avermectin B1a
65195-55-35mg250元
2024/11/08HY-15308阿維菌素 B1a
Avermectin B1a
65195-55-310mM * 1mLin DMSO340元
2024/11/08HY-15308阿維菌素 B1a
Avermectin B1a
65195-55-310mg350元
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