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64302-87-0

中文名稱 R162
英文名稱 R162
CAS 64302-87-0
分子式 C17H12O3
分子量 264.28
MOL 文件 64302-87-0.mol
更新日期 2024/11/08 11:24:24
64302-87-0 結(jié)構(gòu)式 64302-87-0 結(jié)構(gòu)式

基本信息

中文別名
化合物R162
英文別名
R162, >98%
R162
R-162
R 162
2-Allyl-1-hydroxy-9,10-anthraquinone
9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)-

物理化學(xué)性質(zhì)

熔點(diǎn)120-120.5 °C(Solv: acetone (67-64-1))
沸點(diǎn)459.0±34.0 °C(Predicted)
密度1.308±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度可溶于DMSO(高達(dá)10mg/ml)或乙醇(高達(dá)5mg/ml)
酸度系數(shù)(pKa)7.43±0.20(Predicted)
形態(tài)固體
顏色橙色
穩(wěn)定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

常見問題列表

生物活性
R162 是一種有效的谷氨酸脫氫酶 (GDH1/GLUD1) 抑制劑,具有抗癌的作用。
體外研究

Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells.

體內(nèi)研究

R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice.

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