614-47-1
614-47-1 結構式
基本信息
苯丙烯酰苯
苯基苯乙烯基甲酮
苯蘇合香稀甲酮
苯乙烯基本基甲酮
芐差苯乙酮
亞芐基代苯乙酮
查爾酮
1,3-二苯-2-丙烯-1-酮
1,3-二苯基-2-丙烯-1-酮
反-查耳酮,苯乙烯基苯基酮
1,3-DIPHENYL-2-PROPEN-I-ONE
1,3-DIPHENYL-2-PROPENONE
1,3-DIPHENYL-3-PROPEN-1-ONE
1,3-DIPHENYLPROP-2-EN-1-ONE
2-BENZALACETOPHENONE
2-BENZYLIDENEACETOPHENONE
(2E)-1,3-DIPHENYLPROP-2-EN-1-ONE
3-PHENYLACRYLOPHENONE
BENZALACETOPHENONE
BENZYLIDENEACETOPHENONE
BENZYLIDINEACETOPHENONE
CHALCONE
CHALKONE
(E)-CHALCONE
PHENYL STYRYL KETONE
TRANS-BENZYLIDENEACETOPHENONE
TRANS-CHALCONE
(e)-1,3-diphenyl-2-propen-1-one
(e)-benzylideneacetophenone
物理化學性質
安全數(shù)據(jù)
常見問題列表
在氮氣下，將[Ni（dmpymt）2] 6（5 mol％Ni），KOH（1.0 mmol），苯甲醇（1.5 mmol）和1-苯基乙醇（1.0 mmol）與甲苯（2.5 mL）/ t-BuOH（0.5 mL）加入50毫升Schlenk試管中，將試管置于70°C油浴中，在緩慢，穩(wěn)定的氮氣流中攪拌混合物36小時，將混合物冷卻至室溫，加水（10毫升）。 用CH2Cl2（3×10 mL）萃取水溶液，用無水Na2SO4干燥合并的萃取液，除去溶劑，在短時間快速柱色譜上純化粗產物得到反式-查耳酮。
trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a Ki of 48 μM.
trans-Chalcone (30.23-98.03 μM; 24 hours) induces cell cycle arrest and apoptosis in MCF-7 cells.
trans-Chalcone (30.23-98.03 μM; 24 hours) reduces the expression of the apoptosis-related protein Bcl-2 and induces the expression of the CIDEA gene.
trans-Chalcone (58.25 μM; 6, 24 hours) has greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours.
trans-Chalcone (24 hours) inhibits MCF-7 cell viability (IC
20
=30.23 μM; IC
50
=58.25 μM; IC
80
=98.03 μM). trans-Chalcone (48 h) has IC
50
s of 41.53 μM and 48.41 μM for MCF-7 and 3T3 cell lines, respectively. trans-Chalcone exhibits a pronounced cytotoxicity activity.
Apoptosis Analysis
| Cell Line: | MCF-7 cell |
| Concentration: | 30.23, 58.25, 98.03 μM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis of the breast cancer cell line. |
Cell Cycle Analysis
| Cell Line: | MCF-7 cell |
| Concentration: | 30.23, 58.25, 98.03 μM |
| Incubation Time: | 24 hours |
| Result: | Caused cell cycle arrest in G1. |
Western Blot Analysis
| Cell Line: | MCF-7 cell |
| Concentration: | 20, 40, 80 μM |
| Incubation Time: | 24, 48 hours |
| Result: |
Reduced the expression of the apoptosis-related protein Bcl-2 and induced the expression of the CIDEA gene.
There was marked degradation of cyclin D1 at 48 h. |
RT-PCR
| Cell Line: | MCF-7 cell |
| Concentration: | 58.25 μM |
| Incubation Time: | 6, 24 hours |
| Result: | Had greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours. |