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54143-56-5

中文名稱 醋酸洗必太
英文名稱 FLECAINIDE ACETATE
CAS 54143-56-5
分子式 C19H24F6N2O5
分子量 474.39
MOL 文件 54143-56-5.mol
更新日期 2024/11/07 11:03:10
54143-56-5 結(jié)構(gòu)式 54143-56-5 結(jié)構(gòu)式

基本信息

中文別名
乙酸氟卡尼
醋酸氟卡尼
醋酸洗必太
醋酸氟卡胺
氟卡尼醋酸鹽
醋酸氟卡尼 EP標(biāo)準(zhǔn)品
醋酸氟卡尼 USP標(biāo)準(zhǔn)品
氟卡尼系統(tǒng)適應(yīng)性 EP標(biāo)準(zhǔn)品
醋酸洗必太/ 醋酸氟卡尼/乙酸氟卡尼/ N-(哌啶-2-基甲基)-2,5-二(2,2,2-三氟乙氧基)苯甲酰胺乙酸鹽
英文別名
FLAC
r-818
Apocard
Ecrinal
Almarytm
Tambocor
Flucarney Acetate
FLECAINIDE ACETATE
Flecainide-d4 Acetate
Flecainide acetate CRS
所屬類別
原料藥:抗心律失常藥

物理化學(xué)性質(zhì)

熔點(diǎn)145-147℃
儲存條件2-8°C
儲存條件2-8°C
溶解度Soluble in water and in anhydrous ethanol. It is freely soluble in dilute acetic acid and practically insoluble in dilute hydrochloric acid.
溶解度易溶于水和無水乙醇。易溶于稀醋酸,幾乎不溶于稀鹽酸。
形態(tài)neat
顏色白色
水溶解性Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water.
穩(wěn)定性自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 或蒸餾水中的溶液可在 -20°C 下儲存長達(dá) 1 個月。

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
警示詞危險(xiǎn)
危險(xiǎn)性描述H302-H315-H319-H335-H360FD
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼22-36/37/38-63
危險(xiǎn)品運(yùn)輸編號3249
WGK Germany-
WGK Germany-
RTECS號CV5792550
危險(xiǎn)等級6.1(b)
包裝類別III
海關(guān)編碼2933399090

常見問題列表

概述
醋酸洗必太又叫醋酸氟卡胺。醋酸氟卡胺由美國Riker公司研制開發(fā),于1982年首次在德國上市。
用途
醋酸洗必太主要適用于室上性心動過速,房室結(jié)或房室折返心動過速,心房顫動,兒童頑固性交界性心動過速及伴有應(yīng)激綜合征者。
生物活性
Flecainide acetate (R-818) 能阻斷位于心臟的 Nav1.5鈉離子通道,能抗心律失常。
靶點(diǎn)

Nav1.5 channel

體外研究

Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. Flecainide works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. in vitro: Under the current-clamp condition, flecainide (1-100 microM) prolonged the action potential duration at both the early and the late phases of repolarization in a concentration-dependent manner without affecting the resting membrane potential [1]. At a holding potential (HP) of -120 mV, flecainide use-dependently blocked WT and G1306E I(Na) equally but was more potent on R1448C channels. For WT, the extent of block depended on a holding voltage more negative than the activation threshold, being greater at -90 mV as compared to -120 and -180 mV [2]. in vivo: Flecainide (80-130 mg/m(2) orally) resulted in termination of the tachycardia in all 8 patients. Acute pharmacological termination of arrhythmia occurred with oral flecainide loading in 1 and temporarily with intravenous esmolol loading in 1 patient. Adjuvant therapy in form of propranolol was used in 5 and digoxin in 2 [3].

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