53678-77-6
中文名稱
佐劑肽
英文名稱
Muramyl Dipeptide
CAS
53678-77-6
EINECS 編號
258-696-9
分子式
C19H32N4O11
MDL 編號
MFCD00077638
分子量
492.48
MOL 文件
53678-77-6.mol
更新日期
2025/01/24 13:00:12
53678-77-6 結(jié)構(gòu)式
基本信息
中文別名
佐劑肽 英文別名
AC-MURAMYL-ALA-D-GLNAC-MURAMYL-ALA-D-GLU-NH2
AC-MURAMYL-ALA-D-ISOGLN-OH
AC-MURAMYL-ALA-D-ISOGLUTAMINE
ADJUVANT PEPTIDE
MDP
MURAMYL DIPEPTIDE
N-ACETYL-MURAMYL-L-ALA-D-ISOGLN
N-ACETYLMURAMYL-L-ALA-D-ISOGLUTAMINE
N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE
N-AC-MURAMYL-ALA-D-GLU-NH2
N-AC-MURAMYL-ALA-D-GLU-NH2 2H2O
acetylmuramyl-alanyl-isoglutamine
n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutamin
n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutamine
N2-[N-(N-acetylmuramoyl)-L-alanyl]-D-alpha-glutamine
N-Acetylmuramyl-L-alanyl-D-isoglnamine hydrate
n-acetylmuramyl-l-alanyl-d-isoglutamine hydrate
Adjuvant Peptide, Muramyl dipeptide
L-18-MDP
所屬類別
生物化工：多肽物理化學(xué)性質(zhì)
比旋光度D25 +44° (acetic acid)
沸點1071.8±65.0 °C(Predicted)
密度1.390±0.06 g/cm3(Predicted)
儲存條件−20°C
溶解度H2O: 10 mg/mL, clear, colorless
酸度系數(shù)(pKa)4.44±0.10(Predicted)
形態(tài)緩沖水溶液
顏色White to off-white
Merck13,6329
BRN4220745
CAS 數(shù)據(jù)庫53678-77-6(CAS DataBase Reference)
常見問題列表
概述
佐劑肽是指一種通過誘發(fā)、加強和/或促進針對抗原的免疫反應(yīng)來促進或調(diào)節(jié)抗原功能而作為功能性組分(組合物中)的肽。用途
佐劑肽主要用于醫(yī)藥、化工領(lǐng)域。生物活性
Muramyl dipeptide (MDP) 是肽聚糖的共有結(jié)構(gòu)單元。Muramyl dipeptide 通過誘導(dǎo) Runx2 來誘導(dǎo) bone formation。靶點
| Target | Value |
|
Runx2
() |
體外研究
Muramyl dipeptide (0.1-10 μg/mL; 24 hours) increases protein expression of Runx2 in a dose-dependent manner.
Muramyl dipeptide (0.1-10 μg/mL; 6 hours) increases mRNA levels of Runx2 in a dose-dependent manner.
Western Blot Analysis
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.1, 1, 10 μg/mL |
| Incubation Time: | 24 hours |
| Result: | Increased protein expression of Runx2 in a dose-dependent manner. |
RT-PCR
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.1, 1, 10 μg/mL |
| Incubation Time: | 6 hours |
| Result: | Increases mRNA levels of Runx2 in a dose-dependent manner. |
體內(nèi)研究
Muramyl dipeptide (1.25 mg/kg; i.p.; twice) alleviates bone loss induced by osteoporosis.
| Animal Model: | RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice) |
| Dosage: | 1.25 mg/kg |
| Administration: | i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks) |
| Result: | Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb.N). |