4846-19-9
中文名稱
N-去甲荷葉堿
英文名稱
(R)-Nornuciferine
CAS
4846-19-9
分子式
C18H19NO2
分子量
281.35
MOL 文件
4846-19-9.mol
更新日期
2024/12/30 08:59:55
4846-19-9 結(jié)構(gòu)式
基本信息
中文別名
原荷葉堿酸棗仁堿 IA
N-去甲荷葉堿
N-去甲基荷葉堿
N-去甲荷葉堿對(duì)照品
N-去甲荷葉堿標(biāo)準(zhǔn)品
原荷葉堿(N-去甲基荷葉堿)
N-去甲荷葉堿、酸棗仁堿IA、原荷葉堿
英文別名
Sanjoinine IaNornu-ciferine
product/154786
N-Nornuciferine
Daechualkaloid E
(R)-Nornuciferine
N-DesMethylnuciferine
1,2-DiMethoxynoraporphine
(R)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-4H-dibenzo[de,g]quinoline
(6aR)-1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
所屬類別
天然產(chǎn)物：生物堿物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于荷葉。
熔點(diǎn)128-129℃
沸點(diǎn)446.4±45.0 °C(Predicted)
密度1.163±0.06 g/cm3 (20 ºC 760 Torr)
儲(chǔ)存條件Keep in dark place,Sealed in dry,2-8°C
溶解度可溶于DMSO
酸度系數(shù)(pKa)8.29±0.20(Predicted)
形態(tài)固體
顏色Off-white to light yellow
常見(jiàn)問(wèn)題列表
生物活性
N-Nornuciferine是荷葉中的阿樸啡生物堿，可顯著抑制 CYP2D6活性， IC50 和 Ki 值分為3.76 和2.34 μM。靶點(diǎn)
IC50: 3.76 μM (CYP2D6)
Ki: 2.34 μM (CYP2D6)
體外研究
The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent K i values of 2.34 μM.