460330-27-2
中文名稱
GT 949
英文名稱
GT 949
CAS
460330-27-2
分子式
C30H37N7O2
分子量
527.66
MOL 文件
460330-27-2.mol
更新日期
2024/11/07 11:01:32
460330-27-2 結(jié)構(gòu)式
基本信息
中文別名
化合物GT 949化合物 T15446
英文別名
GT 9493-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
2(1H)-Quinolinone, 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-
物理化學(xué)性質(zhì)
沸點(diǎn)770.7±60.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 100 mM; Ethanol: 10 mM, heated
酸度系數(shù)(pKa)10.55±0.70(Predicted)
形態(tài)固體
顏色Off-white to light yellow
GT 949價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-114381 | GT 949 GT 949 | 460330-27-2 | 5mg | 800元 |
| 2024/11/08 | HY-114381 | GT 949 GT 949 | 460330-27-2 | 10mM * 1mLin DMSO | 930元 |
| 2024/11/08 | HY-114381 | GT 949 GT 949 | 460330-27-2 | 10mg | 1400元 |
常見問題列表
生物活性
GT 949 是一種選擇性的興奮性氨基酸轉(zhuǎn)運(yùn)蛋白-2 (EAAT2) 陽性變構(gòu)調(diào)節(jié)劑，EC50 為 0.26 nM。靶點(diǎn)
EC50: 0.26±0.03 nM (EAAT2)
體外研究
GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3.
GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in V
max
of about 47%.