456-12-2
中文名稱
印枳堿
英文名稱
Aegelin
CAS
456-12-2
分子式
C18H19NO3
分子量
297.348
MOL 文件
456-12-2.mol
更新日期
2024/12/17 08:54:05
456-12-2 結(jié)構(gòu)式
基本信息
中文別名
印枳堿N-[2-羥基-2-(4-甲氧基苯基)乙基]肉桂酰胺
英文別名
AegelinAegeline
N-CinnaMoyl-β-hydroxy-4-Methoxyphenyl-aethylaMin
N-Cinnamoyl-β-hydroxy-4-methoxyphenyl-aethylamin
N-(2-Hydroxy-2-(4-Methoxyphenyl)ethyl)cinnaMaMide
(E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]cinnamamide
(E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
Aegeline,N-[2-hydroxy-2(4-Methoxyphenyl) ethyl]-3-phenyl-2-propenaMide
2-Propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)-
AegelineQ: What is Aegeline Q: What is the CAS Number of Aegeline Q: What is the storage condition of Aegeline Q: What are the applications of Aegeline
所屬類別
醫(yī)藥中間體：原料藥中間體物理化學(xué)性質(zhì)
熔點(diǎn)178-179℃
儲(chǔ)存條件under inert gas (nitrogen or Argon) at 2-8°C
形態(tài)粉末晶體
顏色白色至淺黃色
常見(jiàn)問(wèn)題列表
用途
印枳堿是一種化合物，可以從生長(zhǎng)在印度的Aegle marmelos樹(shù)的葉子中提取。研究發(fā)現(xiàn)這種樹(shù)的精油對(duì)21種細(xì)菌有效。印枳堿也有抗肥胖作用。
用途
印枳堿為芳香類衍生物，其可用作醫(yī)藥合成中間體。生物活性
Aegeline 是一種主要生物堿，模擬酵母 SNARE 蛋白 Sec22p 抑制酵母 α-突觸核蛋白和 Bax 毒性。Aegeline 恢復(fù) αsyn 或 Bax 抑制的酵母細(xì)胞生長(zhǎng)。體外研究
Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or
Bax-expressing cells.
Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin.