42895-58-9
中文名稱
穿心蓮內(nèi)酯
英文名稱
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
CAS
42895-58-9
分子式
C20H28O4
分子量
332.43
MOL 文件
42895-58-9.mol
更新日期
2024/11/04 17:03:02
42895-58-9 結(jié)構(gòu)式
基本信息
中文別名
雄茸交酯穿心蓮內(nèi)酯雜質(zhì)1
14-去氧-11
14-脫水穿心蓮內(nèi)酯
12-二去氫穿心蓮內(nèi)酯
穿心蓮內(nèi)酯 穿心蓮乙素
14-脫氧-11,12- 穿心蓮內(nèi)酯
14-脫氧11,14-二脫氫穿心蓮內(nèi)酯
14-脫氧-11,12-二去氫穿心蓮內(nèi)酯
14-去氧-11,12-二去氫穿心蓮內(nèi)酯
英文別名
AP 1014-dehydro Andrographolide
Andrographolide Impurity 1
14-Deoxy-11,12-didehydroandrographol
14-Deoxy-11,14-didehydroandrographolide
11,12-Didehydro-14-deoxyandrographolide
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
Deoxy-11,12-Didehydroandrographolide, 14-
14-Deoxy-11,12-didehydroandrographolide?, >98%
3,19-Dihydroxylabda-8(17),11,13-trien-16,15-olide
所屬類別
原料藥：天然來源抗感染藥物理化學(xué)性質(zhì)
熔點(diǎn)204-205℃
沸點(diǎn)519.6±50.0 °C(Predicted)
密度1.17
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml
酸度系數(shù)(pKa)14.80±0.70(Predicted)
形態(tài)neat
顏色White to off-white
穿心蓮內(nèi)酯價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-N1490 | 穿心蓮內(nèi)酯 14-Deoxy-11,12-didehydroandrographolide | 42895-58-9 | 1mg | 600元 |
| 2024/11/08 | HY-N1490 | 穿心蓮內(nèi)酯 14-Deoxy-11,12-didehydroandrographolide | 42895-58-9 | 10mM * 1mLin DMSO | 1390元 |
| 2024/11/08 | HY-N1490 | 穿心蓮內(nèi)酯 14-Deoxy-11,12-didehydroandrographolide | 42895-58-9 | 5mg | 1900元 |
常見問題列表
生物活性
14-Deoxy-11,12-didehydroandrographolide 是 Andrographolide 的類似物。14-Deoxy-11,12-didehydroandrographolide 抑制 NF-κB 活化。靶點(diǎn)
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NF-κB
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體外研究
14-deoxy-11,12-didehydroandrographolide, a naturally occurring noncytotoxic analogue of Andrographolide, effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment into bronchoalveolar lavage (BAL) fluid, IL-4, IL-5, IL-13, and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness (AHR) in a mouse asthma model, probably via inhibition of NF-κB activity.
體內(nèi)研究
14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine.