400827-46-5
中文名稱
頭孢羅林酯
英文名稱
TAK 599
CAS
400827-46-5
分子式
C24H25N8O10PS4
分子量
744.72
MOL 文件
400827-46-5.mol
更新日期
2023/03/20 15:41:25
400827-46-5 結(jié)構(gòu)式
基本信息
中文別名
頭孢羅林酯頭孢洛林酯雜質(zhì)
頭孢洛林酯乙酸鹽
頭孢洛林酯雜質(zhì)對照品
CEFTAROLINE FOSAMIL醋酸鹽
英文別名
TAK 599PPI 0903
Ceftaroline fosaMil
C22H22N8O8PS4. C2H3O2
Ceftaroline Fosamil Acetate
TAK-599 (ceftaroline fosamil)
Ceftaroline fosamil acetate salt
TAK-599
CEFTAROLINE FOSAMIL
TAK599
TAK 599
PPI-0903
PPI0903
PPI 0903
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMSO : 30 mg/mL (40.28 mM; Need ultrasonic and warming)
形態(tài)粉末
顏色White to light yellow
常見問題列表
生物活性
Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) 是一種頭孢菌素，對 Gram-positive pathogens (包括耐甲氧西林的金黃色葡萄球菌(MRSA))具有活性。體內(nèi)研究
Ceftaroline fosamil is effective against all 10 MRSA isolates used in the dose-ranging studies and requires approximately 17 to 43% f T>MIC (the percentage of time that free drug concentrations remain above the MIC) to produce a 1-log 10 kill. The Ceftaroline Fosamil treatment results in mean reductions of 1.1 to 2.4 log 10 CFU, with no relationship to the Ceftaroline Fosamil MIC. The use of high inocula does not affect the Ceftaroline Fosamil efficacy against the three strains tested, with mean decreases of 2.0 to 3.0 log 10 CFU.