329198-87-0
329198-87-0 結(jié)構(gòu)式
基本信息
2-Furancarboxamide, N-3-dibenzofuranyl-5-nitro-
N-(3-Dibenzofuranyl)-5-nitro-2-furancarboxamide
N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide
物理化學(xué)性質(zhì)
常見問題列表
| Target | Value |
|
STING
() |
C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells.C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1.C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts.
Western Blot Analysis
| Cell Line: | Mouse bone marrow-derived macrophages (BMDMs) |
| Concentration: | 0 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM |
| Incubation Time: | 1 hour |
| Result: | Inhibited CMA-induced p-TBK1 expression as a does dependent manner. |
RT-PCR
| Cell Line: | Mouse bone marrow-derived macrophages (BMDMs) |
| Concentration: | 1 μM |
| Incubation Time: | 1 hour |
| Result: | Downregulated Ifnb1 expression in BMDMs. |
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | S6667 | N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺 STING inhibitor C-178 | 329198-87-0 | 2mg | 1700.35元 |
| 2024/11/08 | S6667 | N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺 STING inhibitor C-178 | 329198-87-0 | 5mg | 2370元 |
| 2024/11/08 | S6667 | STING inhibitor C-178 | 329198-87-0 | 10mM (1mL in DMSO) | 2694.51元 |