328232-95-7
中文名稱
MK 0557
英文名稱
MK 0557
CAS
328232-95-7
分子式
C22H19FN4O3
分子量
406.41
MOL 文件
328232-95-7.mol
更新日期
2024/06/25 17:16:04
328232-95-7 結構式
基本信息
中文別名
反式-N-[1-(2-氟苯基)-1H-吡唑-3-基]-1'-氧代螺[環(huán)己烷-1,3'(1'H)-呋喃并[3,4-C]吡啶]-4-甲酰胺 英文別名
MK 0557CS-2471
MK0557
MK 0557
N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester
N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide
trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide
(1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
Spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide, N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-, trans-
所屬類別
生物化工：激動劑抑制劑物理化學性質
熔點240.0-240.6 °C
沸點708.7±60.0 °C(Predicted)
密度1.46±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml
酸度系數(pKa)13.40±0.20(Predicted)
形態(tài)結晶固體
顏色White to off-white
應用領域
用途1
一種選擇性很強的口服神經肽NPY5R拮抗劑,Ki:1.6nM。MK-0557 is a highly selective, orally administered neuropeptide NPY5R antagonist, could limit weight regain after very-low-calorie diet (VLCD)-induced weight loss. Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target.