3106-85-2
中文名稱
異冬谷酸
英文名稱
N-acetyl aspartyl-glutaMic acid
CAS
3106-85-2
分子式
C11H16N2O8
分子量
304.25
MOL 文件
3106-85-2.mol
更新日期
2024/12/23 10:30:28
3106-85-2 結(jié)構(gòu)式
基本信息
中文別名
異冬谷酸鹽酸索他洛爾-D6
N-乙?；?L-天冬氨酰-L-谷氨酸
英文別名
NAAGNAAGA
Naaxia
ZY-15106
AC-ASP-GLU
ALPHA-NAAG
ACETYL-D-E
AC-ASP-GLU-OH
AC-ASP-GLU H2O
SPAGLUMIC ACID
所屬類別
生物化工：多肽物理化學(xué)性質(zhì)
熔點(diǎn)171-173 °C
沸點(diǎn)769.5±60.0 °C(Predicted)
密度1.472±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度H2O: 50 mg/mL
溶解度H2O:50 mg/mL
酸度系數(shù)(pKa)3.04±0.10(Predicted)
形態(tài)powder
顏色white
旋光性 (optical activity)[α]22/D 34.5°, c = 1.1 in H2O(lit.)
水溶解性溶于水至100mM
穩(wěn)定性吸濕性
安全數(shù)據(jù)
警示詞警告
危險性描述H315-H319-H335
危險品標(biāo)志Xi
危險類別碼36/37/38
安全說明26-36
WGK Germany3
WGK Germany3
海關(guān)編碼29241990
常見問題列表
生物活性
Spaglumic Acid (N-Acetylaspartylglutamic acid) 是一種在腦中以毫摩爾濃度存在的神經(jīng)肽。靶點(diǎn)
|
Human Endogenous Metabolite
|
體外研究
Spaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca 2+ -dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders.