306-07-0
306-07-0 結(jié)構(gòu)式
基本信息
丙炔甲基芐胺
巴吉林鹽酸鹽
巴吉林,優(yōu)降寧
優(yōu)降寧 鹽酸鹽
鹽酸帕吉林 標(biāo)準(zhǔn)品
N-甲基-N-炔丙基芐胺鹽酸鹽
N-甲基-N-丙炔基芐胺 鹽酸鹽
巴吉林鹽酸鹽,丙炔甲基芐胺,巴吉林
N-甲基-N-2-丙炔基芐胺 鹽酸鹽
pargyline hcl
Parguline HCL
pargylinechloride
PARGYLINE HYDROCHLOR
PARGYLINE HYDROCHLORIDE
Parglycine hydrochloride
Pargylamine hydrochloride
Pargyline Hydrochloride (200 mg)
PARGYLINE HYDROCHLORIDE USP/EP/BP
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
| Target | Value |
|
MAO-B
(Cell-free assay) | 0.5 μM(Ki) |
|
MAO-A
(Cell-free assay) | 13 μM(Ki) |
Pargyline (0.5-2 mM; 24-120 hours; LNCaP-LN3 cells) treatment inhibits the proliferation of prostate cancer cells in a time- and dose-dependent manner.
Pargyline (0.5-2 mM; 24-48 hours; LNCaP-LN3 cells) treatment decreases S phase and increases the G1 phase in the cells in a dose-dependent manner.
Pargyline (0.5 mM; 24 hours; LNCaP-LN3 cells) treatment increases the apoptotic cells.
Pargyline (2 mM; 48 hours; LNCaP-LN3 cells) treatment induces an increase of cytochrome c and a decrease of caspase-3 in the cells, but does not lead to a change of BCL-2 expression.
Cell Proliferation Assay
| Cell Line: | LNCaP-LN3 cells |
| Concentration: | 0.5 mM, 1 mM, 1.5 mM or 2 mM |
| Incubation Time: | 24 hours, 48 hours, 72 hours, 96 hours or 120 hours |
| Result: | Inhibited the proliferation of prostate cancer cells in a time- and dose-dependent manner. |
Cell Cycle Analysis
| Cell Line: | LNCaP-LN3 cells |
| Concentration: | 0.5 mM, 2 mM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | The S phase ratio of the cells was decreased, while their G1 phase ratio was increased. |
Apoptosis Analysis
| Cell Line: | LNCaP-LN3 cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 24 hours |
| Result: | Increased the apoptotic cells. |
Western Blot Analysis
| Cell Line: | LNCaP-LN3 cells |
| Concentration: | 2 mM |
| Incubation Time: | 48 hours |
| Result: | Induced an increase of cytochrome c and a decrease of caspase-3. |
Pargyline (10 mg/kg; iv) treatment induces a moderate (about 20 mm Hg) but persistent (48 h) decrease of systolic blood pressure in unanesthetized adult spontaneously hypertensive rats (SHR) but not in normotensive rats.
A low dose of Pargyline (200 μg; icv) injected directly into the brain lowered arterial pressure. The hypotensive action of Pargylline in SHR appears to be the consequence of Norepinephrine accumulating at an inhibitory α-adrenoceptor in brain.