300-84-5
300-84-5 結構式
基本信息
亞?；撬?/span>
2-AMINOETHANESULFUNIC ACID
2-AMINOETHYLSULFINIC ACID
HYPOTAURINE
hypotaurine crystalline
Ethanesulfinic acid, 2-amino-
物理化學性質(zhì)
安全數(shù)據(jù)
常見問題列表
亞?；撬崾桥；撬岬那绑w之一，經(jīng)過氧化變?yōu)榕；撬幔溉閯游镏饕ㄟ^這條途徑合成，而合成?；撬岬难趸甘且粋€非限速的，所以可以保持一個平衡。晶體的溶解度只有6－7％，亞牛磺酸鈉要高一些。
自1975年Hayes等報道，缺乏?；撬釙е掠棕堃暪δ軠p退甚至失明后，人們對?；撬岬臓I養(yǎng)作用越來越關注。
先在發(fā)現(xiàn)的?；撬峁δ芎芏?，但主要是促進細胞膜對糖的吸收，此外還可作用于胰島素受體，發(fā)揮胰島素樣效應。
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Human Endogenous Metabolite
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Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion.
Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord.