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2673-40-7

中文名稱 派利文堿
CAS 2673-40-7
分子式 C20H22N2O3
分子量 338.4
MOL 文件 2673-40-7.mol
2673-40-7 結(jié)構(gòu)式 2673-40-7 結(jié)構(gòu)式

基本信息

中文別名
派利文堿1
派利文堿對照品
派利文堿標準品
英文別名
Perivin
Poly alkali
4-Demethyl-3-oxovobasan-17-oic acid methyl ester
Vobasan-17-oic acid,4-demethyl-3-oxo-, methyl ester
Vobassan-17-oic acid, 4-demethyl-3-oxo-, methyl ester
5-Ethylidene-2,3,4,5,6,7,8,9-octahydro-8-oxo-2,6-methano-1H-azecino[5,4-b]indole-14-carboxylic acid methyl ester

物理化學(xué)性質(zhì)

熔點180-181℃
比旋光度D26 -121.4° (chloroform)
密度1.273
酸度系數(shù)(pKa)pKa in 66% DMF: 7.5(at 25℃)

常見問題列表

生物活性
Perivine (Perivin) 以視網(wǎng)膜母細胞瘤相關(guān)蛋白 (RbAp48) 為靶點，用于解決 RbAp48-FOG-1 復(fù)合物的不穩(wěn)定性。Perivine 可用于阿爾茨海默病的研究。
靶點

IC50: Retinoblastoma-associated proteins (RbAp48)

體外研究

Retinoblastoma-associated proteins (RbAp48) are related to Alzheimer's disease (AD), RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription. However, this is an unstable complex may affect the function of RbAp48. Perivine has a greater stable affinity for RbAp48 binding than FOG1, it might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy.

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